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Evaluation of liver fibrosis using Raman spectroscopy and infrared thermography: A pilot study.
Ramírez-Elías, Miguel G; Kolosovas-Machuca, E S; Kershenobich, David; Guzmán, Carolina; Escobedo, Galileo; González, Francisco J.
Afiliação
  • Ramírez-Elías MG; Universidad Autónoma de San Luis Potosí, Facultad de Ciencias, Lateral Av. Salvador Nava s/n, San Luis Potosí, 78290, Mexico.
  • Kolosovas-Machuca ES; Universidad Autónoma de San Luis Potosí, Coordinación para la Innovación y la Aplicación de la Ciencia y la Tecnología, Av. Sierra Leona #550, San Luis Potosí, 78210, Mexico.
  • Kershenobich D; Universidad Nacional Autónoma de México, Unidad de Medicina Experimental, Facultad de Medicina, Hospital General de México "Dr. Eduardo Liceaga", Dr. Balmis 148, Ciudad de México, 06726, Mexico.
  • Guzmán C; Universidad Nacional Autónoma de México, Unidad de Medicina Experimental, Facultad de Medicina, Hospital General de México "Dr. Eduardo Liceaga", Dr. Balmis 148, Ciudad de México, 06726, Mexico.
  • Escobedo G; Universidad Nacional Autónoma de México, Unidad de Medicina Experimental, Facultad de Medicina, Hospital General de México "Dr. Eduardo Liceaga", Dr. Balmis 148, Ciudad de México, 06726, Mexico.
  • González FJ; Universidad Autónoma de San Luis Potosí, Coordinación para la Innovación y la Aplicación de la Ciencia y la Tecnología, Av. Sierra Leona #550, San Luis Potosí, 78210, Mexico. Electronic address: javier.gonzalez@uaslp.mx.
Photodiagnosis Photodyn Ther ; 19: 278-283, 2017 Sep.
Article em En | MEDLINE | ID: mdl-28754542
Liver fibrosis is a pathological process that can escalate to cirrhosis and then liver failure, a major public health concern that affect hundreds of millions of people in both developed and developing countries. Detection of liver fibrosis during its earlier stages is a matter of great importance which may allow prevention of development of cirrhosis in patients with chronic liver disease. In this work, Raman spectroscopy and thermography were evaluated to detect early pathological signs of liver fibrosis in rats in which liver fibrosis was induced using carbon tetrachloride. Results show that Raman spectra of healthy and fibrotic livers significantly differ among each other and can be classified by principal component analysis and discriminant analysis. The PCA-LDA method has a sensitivity of 100%, specificity 85% and diagnostic accuracy of 93.5%. Thermography also revealed characteristic temperature patterns for fibrotic livers compared to healthy livers. Current data suggest that Raman spectroscopy and thermography could be used to detect fibrosis in ex vivo liver samples.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise Espectral Raman / Termografia / Cirrose Hepática Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Photodiagnosis Photodyn Ther Assunto da revista: DIAGNOSTICO POR IMAGEM / TERAPEUTICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: México País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise Espectral Raman / Termografia / Cirrose Hepática Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Photodiagnosis Photodyn Ther Assunto da revista: DIAGNOSTICO POR IMAGEM / TERAPEUTICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: México País de publicação: Holanda