Effect of tunable redox behavior of bis chelate substituted 1,10-phenantroline Cu(II) complexes on its reaction with superoxide anion in DMSO. Toward a simple criterion to identify a SOD-like mechanism.
J Inorg Biochem
; 175: 118-128, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28753490
In this work we report a series of Cu(II) complexes [Cu(N-N)2(X)]+, (N-N=substituted 1,10-phenanthroline derivatives and X=Cl- or NO3-), with tunable E1/2 for electrochemical reduction [CuII(N-N)2(X)]++1e-â[CuI(N-N)2]+X-. The disproportion of O2â¢- was explored in presence of the electro-generated species [CuI(N-N)2]+ using cyclic voltammetry in a non-aqueous media, arising a new simple method to propose a SOD-like mechanism, which can be used as a quick guide test for a compound, before being proven in biological assays. It was found that complexes with high negative half wave potential values (E1/2) for Cu(II)/Cu(I) couple shown a current increment for oxygen reduction, related to the capability of the disproportion of this reactive oxygen species.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenantrolinas
/
Superóxido Dismutase
/
Quelantes
/
Dimetil Sulfóxido
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Superóxidos
/
Cobre
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Inorg Biochem
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Estados Unidos