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[Vertebral fractures in children with Type I Osteogenesis imperfecta]. / Fracturas vertebrales en niños con osteogénesis imperfecta tipo I.
Sepúlveda, Andrea M; Terrazas, Claudia V; Sáez, Josefina; Reyes, María L.
Afiliação
  • Sepúlveda AM; Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Terrazas CV; Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Sáez J; Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Reyes ML; Pontificia Universidad Católica de Chile, Santiago, Chile.
Rev Chil Pediatr ; 88(3): 348-353, 2017 Jun.
Article em Es | MEDLINE | ID: mdl-28737193
Osteogenesis imperfecta (OI) is an hereditary disease affecting conective tissue, mainly associated to growth retardation and pathological fractures. OI type I (OI type I), is the mildest, most often, and homogeneous in its fenotype. Vertebral fractures are the most significant complications, associated to skeletical and cardiopulmonary morbidity. OBJECTIVES: To characterize clinically a cohort of children with OI type I. PATIENTS AND METHODS: A cohort of OI type I children younger than 20 year old was evaluated. Demographic, clinical, biochemical and radiological data were registered. RESULTS: Sixty seven patients were included, 55% male, 69% resident in the Metropolitan Region. The mean age of diagnose was 2.9 years, 70% presented vertebral fractures on follow-up, mostly thoracic, and 50% before the age of 5 years. Fifty percentage presented vertebral fractures at diagnose, which was about the age of 5 years. Bone metabolic parameters were in the normal range, without significant change at the moment of vertebral fractures. Calcium intake was found to be below American Academy of Pediatrics recommendations at the time of the first fracture. CONCLUSIONS: In this study OI type I has an early diagnose, and vertebral fractures show a high incidence, mostly in toddlers. Calcium intake was found to be below reccomended values, and should be closely supervised in these patients.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese Imperfeita / Vértebras Torácicas / Fraturas da Coluna Vertebral / Vértebras Lombares Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: Es Revista: Rev Chil Pediatr Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Chile País de publicação: Chile

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese Imperfeita / Vértebras Torácicas / Fraturas da Coluna Vertebral / Vértebras Lombares Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: Es Revista: Rev Chil Pediatr Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Chile País de publicação: Chile