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Impact of alcohol consumption among patients in hepatitis C virus treatment.
Vieira-Castro, Andréa Carvalho Maia; Oliveira, Luiz Carlos Marques de.
Afiliação
  • Vieira-Castro ACM; Programa de Pós-graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Uberlândia, Uberlândia, MG, Brasil.
  • Oliveira LCM; Programa de Pós-graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Uberlândia, Uberlândia, MG, Brasil.
Arq Gastroenterol ; 54(3): 232-237, 2017.
Article em En | MEDLINE | ID: mdl-28724048
BACKGROUND:: Recent studies have questioned the recommendation of abstinence from alcohol for at least 6 months for alcoholic patients to be treated for hepatitis C. OBJECTIVE:: The present study aimed to assess the impact of alcohol consumption among patients undergoing hepatitis C treatment. METHODS:: In this cross-sectional study, 121 patients [78 (64.5%) men; 28-70 years] were evaluated. They were divided as follows: patients who consumed <12 g of ethanol/day throughout life (Group 1), 12-59 g/day (Group 2) and ≥60 g/day (Group 3). Patients were treated with pegyla-ted-interferon plus ribavirin. RESULTS:: These three groups could not be distinguished in terms of the severity of liver fibrosis and frequency of HCV genotype-1 infection. In Group 3, treatment discontinuation (32.4%) was higher than in the Group 1 (9.4%) or Group 2 (0%), it was higher among patients who drank during treatment (66.7% vs 21.4%) and among those who had not been abstinent for at least 6 months (72.7% vs 15.4%). Moderate alcohol drinkers showed good adherence and did not discontinue the treatment. The frequencies of sustained viral response among patients in Group 3 (44.4%) were similar to those in Group 1 (61%) and Group 2 (68.4%). CONCLUSION:: Heavy drinkers more often discontinued treatment for hepatitis C, but those that received this treatment had acceptable sustained viral response rates. These results suggest that heavy drinkers should not be systematically excluded from the treatment, but they should be monitored to avoid drinking and abandoning treatment, mainly those who have not been abstinent for at least 6 months.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Ribavirina / Interferon-alfa / Hepatite C / Alcoolismo Tipo de estudo: Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Gastroenterol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Ribavirina / Interferon-alfa / Hepatite C / Alcoolismo Tipo de estudo: Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Gastroenterol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil