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Experimental Infection with and Maintenance of Cell Fusing Agent Virus (Flavivirus) in Aedes aegypti.
Contreras-Gutierrez, Maria Angelica; Guzman, Hilda; Thangamani, Saravanan; Vasilakis, Nikos; Tesh, Robert B.
Afiliação
  • Contreras-Gutierrez MA; Grupo de Investigacion en Sistematica Molecular (GSM), Facultad de Ciencias, Universidad Nacional de Colombia, Medellin, Colombia.
  • Guzman H; Programa de Estudio y Control de Enfermedades Tropicales (PECET), Sede de Investigacion Universitaria (SIU), Universidad de Antioquia, Medellin, Colombia.
  • Thangamani S; Department of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.
  • Vasilakis N; Department of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.
  • Tesh RB; Department of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.
Am J Trop Med Hyg ; 97(1): 299-304, 2017 Jul.
Article em En | MEDLINE | ID: mdl-28719335
During the past two decades, there has been a dramatic increase in the recognition and characterization of novel insect-specific flaviviruses (ISFVs). Some of these agents are closely related to important mosquito-borne flavivirus pathogens. Results of experimental studies suggest that mosquitoes and mosquito cell cultures infected with some ISFVs are refractory to superinfection with related flavivirus pathogens; and it has been proposed that ISFVs potentially could be used to alter the vector competence of mosquitoes and reduce transmission of specific flavivirus pathogens, such as dengue, West Nile, or Zika viruses. In order for an ISFV to be used in such a control strategy, the virus would have to be vertically transmitted at a high rate in the target vector population to insure its continued maintenance. This study compared the vertical transmission rates of an ISFV, cell fusing agent virus (CFAV), in two Aedes aegypti colonies: one naturally infected with CFAV and the other experimentally infected but previously free of the virus. CFAV filial infection rates in progeny of female mosquitoes from both colonies were > 90% after two generations of selection, indicating the feasibility of introducing an ISFV into a mosquito population. This and other considerations for evaluating the feasibility of using ISFVs as an arbovirus control strategy are discussed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aedes / Flavivirus / Vírus de Insetos Limite: Animals Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aedes / Flavivirus / Vírus de Insetos Limite: Animals Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos