Reduced first-phase insulin secretion increases postprandial lipidemia in subjects with impaired glucose tolerance.

Gómez-Sámano, Miguel Ángel; Cuevas-Ramos, Daniel; Grajales-Gómez, Mariana; Escamilla-Márquez, Marco; López-Estrada, Angelina; Guillén-Pineda, Luz Elizabeth; López-Carrasco, Guadalupe; Gómez-Pérez, Francisco J

Gómez-Sámano, Miguel Ángel; Cuevas-Ramos, Daniel; Grajales-Gómez, Mariana; Escamilla-Márquez, Marco; López-Estrada, Angelina; Guillén-Pineda, Luz Elizabeth; López-Carrasco, Guadalupe; Gómez-Pérez, Francisco J.

Afiliação

Gómez-Sámano MÁ; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
Cuevas-Ramos D; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
Grajales-Gómez M; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
Escamilla-Márquez M; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
López-Estrada A; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
Guillén-Pineda LE; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
López-Carrasco G; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
Gómez-Pérez FJ; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.

BMJ Open Diabetes Res Care ; 5(1): e000344, 2017.

Article em En | MEDLINE | ID: mdl-28713570

RESUMO

OBJECTIVE: It is not clear which phase of insulin secretion is more important to regulate lipoprotein lipase (LPL) activity. After a meal, insulin is released and acts as a major regulator of LPL activity. Postprandial hyperlipidemia is a common comorbidity in subjects with insulin resistance (IR). Therefore this study aimed to evaluate the role of the first-phase insulin secretion (FPIS) on postprandial lipidemia in subjects with IR and impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS: This is a cross-sectional, observational and comparative study. We included male and female subjects between 40 and 60 years with a body mass index (BMI) between 23 and 30 kg/m2. Then, patients were divided into three groups. Group 1 consisted of control subjects with normal glucose tolerance and preserved FPIS. Group 2 included patients with IGT and a reduced FPIS. Group 3 consisted of subjects with IGT but normal FPIS. Both groups were paired by age and BMI with subjects in the control group. Subjects underwent an intravenous glucose tolerance test to classify each case, and then a load with a mixed meal load to measure postprandial lipidemia. RESULTS: A total of 32 subjects were evaluated: 10 were control subjects, 8 subjects with IGT with a reduced FPIS and 14 subjects with IGT and preserved FPIS. After administration of a standardized meal, group 2 showed a greater glucose area under the curve (AUC) at 30 and 120 min (p=0.001, for both). This group also showed a statistically significant increase (p<0.001) in triglyceride AUC. CONCLUSIONS: A reduced FPIS is significantly and independently associated with a larger postprandial hyperlipidemia in subjects with IGT.

Palavras-chave

fist-phase insulin secretion; postprandial lipidemia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: BMJ Open Diabetes Res Care Ano de publicação: 2017 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido

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