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Fat Mass Lowers the Response to Tumor Necrosis Factor-α Blockers in Patients with Ankylosing Spondylitis.
Ibáñez Vodnizza, Sebastián E; Nurmohamed, Michael T; Visman, Ingrid M; van Denderen, J Christiaan; Lems, Willem F; Jaime, Francisca; van der Horst-Bruinsma, Irene E.
Afiliação
  • Ibáñez Vodnizza SE; From the Amsterdam Rheumatology and Immunology Center, Reade and VU University Medical Center, Amsterdam, the Netherlands; Rheumatology Department, Clínica Alemana de Santiago and Hospital Padre Hurtado, Santiago, Chile.
  • Nurmohamed MT; S.E. Ibáñez Vodnizza, MD, Rheumatology Department, Clínica Alemana de Santiago and Hospital Padre Hurtado; M.T. Nurmohamed, MD, Professor, Amsterdam Rheumatology and Immunology Center, Reade and VU University Medical Center; I.M. Visman, Amsterdam Rheumatology and Immunology Center, Reade; J.C. van
  • Visman IM; From the Amsterdam Rheumatology and Immunology Center, Reade and VU University Medical Center, Amsterdam, the Netherlands; Rheumatology Department, Clínica Alemana de Santiago and Hospital Padre Hurtado, Santiago, Chile.
  • van Denderen JC; S.E. Ibáñez Vodnizza, MD, Rheumatology Department, Clínica Alemana de Santiago and Hospital Padre Hurtado; M.T. Nurmohamed, MD, Professor, Amsterdam Rheumatology and Immunology Center, Reade and VU University Medical Center; I.M. Visman, Amsterdam Rheumatology and Immunology Center, Reade; J.C. van
  • Lems WF; From the Amsterdam Rheumatology and Immunology Center, Reade and VU University Medical Center, Amsterdam, the Netherlands; Rheumatology Department, Clínica Alemana de Santiago and Hospital Padre Hurtado, Santiago, Chile.
  • Jaime F; S.E. Ibáñez Vodnizza, MD, Rheumatology Department, Clínica Alemana de Santiago and Hospital Padre Hurtado; M.T. Nurmohamed, MD, Professor, Amsterdam Rheumatology and Immunology Center, Reade and VU University Medical Center; I.M. Visman, Amsterdam Rheumatology and Immunology Center, Reade; J.C. van
  • van der Horst-Bruinsma IE; From the Amsterdam Rheumatology and Immunology Center, Reade and VU University Medical Center, Amsterdam, the Netherlands; Rheumatology Department, Clínica Alemana de Santiago and Hospital Padre Hurtado, Santiago, Chile.
J Rheumatol ; 44(9): 1355-1361, 2017 Sep.
Article em En | MEDLINE | ID: mdl-28711878
OBJECTIVE: Our main objective was to assess the relationship between body composition (BC) and response to tumor necrosis factor-α (TNF-α) blocker treatment in patients with ankylosing spondylitis (AS). Our secondary objective was to evaluate the change of BC after treatment, accounting for sex and age. METHODS: All included patients fulfilled the modified New York criteria for AS and were naive to TNF-α blocker. They were followed for at least 6 months after the start of etanercept or adalimumab. The Ankylosing Spondylitis Disease Activity Score containing C-reactive protein (ASDAS-CRP) and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were reported. BC was assessed by whole body dual-energy X-ray absorptiometry. Body fat percentage (BF%), fat mass index (FMI), and fat free mass index (FFMI) were reported as absolute values and as percentiles. RESULTS: Forty-one patients were included (61% men). The median followup was 14.3 months (interquartile range 8.4-19.4). After multivariate regression analysis, more fat at baseline (BF%, FMI, or FMI percentile) was significantly related with a lower chance of achieving a clinically important improvement of the ASDAS-CRP or BASDAI after treatment. The body composition did not change significantly after treatment, but there was a trend toward muscle recovery in men (FFMI change from 34.0th to 37.4th percentile). CONCLUSION: Higher body fat content at baseline was independently associated with a worse response to treatment with TNF-α blockers, measured by ASDAS-CRP and BASDAI change, and might contribute to the lower response rates in female patients. Also, there is a trend toward muscle mass recovery in male patients after treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espondilite Anquilosante / Antirreumáticos / Adiposidade / Adalimumab / Etanercepte Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Rheumatol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Chile País de publicação: Canadá
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espondilite Anquilosante / Antirreumáticos / Adiposidade / Adalimumab / Etanercepte Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Rheumatol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Chile País de publicação: Canadá