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Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment.
Strong Rodrigues, Karla; Oliveira-Ribeiro, Carla; de Abreu Fiuza Gomes, Silvia; Knobler, Robert.
Afiliação
  • Strong Rodrigues K; Centro de Transplante de Medula Óssea-CEMO, Instituto Nacional de Câncer José Alencar Gomes da Silva-INCA, Rio de Janeiro, Brazil.
  • Oliveira-Ribeiro C; Centro de Transplante de Medula Óssea-CEMO, Instituto Nacional de Câncer José Alencar Gomes da Silva-INCA, Rio de Janeiro, Brazil.
  • de Abreu Fiuza Gomes S; Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil.
  • Knobler R; Department of Dermatology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. robert.knobler@meduniwien.ac.at.
Am J Clin Dermatol ; 19(1): 33-50, 2018 Feb.
Article em En | MEDLINE | ID: mdl-28656563
Graft-versus-host disease (GVHD) is an immunological reaction and a frequent complication following allogeneic hematopoietic stem cell transplantation. It is associated with high mortality rates and may have a significant negative impact on the patient's quality of life, particularly in the chronic-stage setting. Many different organs can be involved, which leads to a wide range of clinical manifestations. In this context, dermatologists play a key role by diagnosing and treating GVHD from the outset since cutaneous features are not just the most common but are also usually the presenting sign. Several skin-direct therapies are available and may be indicated as monotherapy or adjuvant treatment in order to allow faster tapering and withdrawal of systemic immunosuppression. Treatment of steroid-refractory patients remains a challenge and, to date, no consensus has been reached for one single agent in second-line therapy. This article aims to review skin involvement as well as provide and update discussion on therapeutic options for both acute and chronic cutaneous GVHD.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dermatopatias / Terapia de Imunossupressão / Transplante de Células-Tronco Hematopoéticas / Fármacos Dermatológicos / Doença Enxerto-Hospedeiro Tipo de estudo: Diagnostic_studies Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Am J Clin Dermatol Assunto da revista: DERMATOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Nova Zelândia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dermatopatias / Terapia de Imunossupressão / Transplante de Células-Tronco Hematopoéticas / Fármacos Dermatológicos / Doença Enxerto-Hospedeiro Tipo de estudo: Diagnostic_studies Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Am J Clin Dermatol Assunto da revista: DERMATOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Nova Zelândia