Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment.
Am J Clin Dermatol
; 19(1): 33-50, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-28656563
Graft-versus-host disease (GVHD) is an immunological reaction and a frequent complication following allogeneic hematopoietic stem cell transplantation. It is associated with high mortality rates and may have a significant negative impact on the patient's quality of life, particularly in the chronic-stage setting. Many different organs can be involved, which leads to a wide range of clinical manifestations. In this context, dermatologists play a key role by diagnosing and treating GVHD from the outset since cutaneous features are not just the most common but are also usually the presenting sign. Several skin-direct therapies are available and may be indicated as monotherapy or adjuvant treatment in order to allow faster tapering and withdrawal of systemic immunosuppression. Treatment of steroid-refractory patients remains a challenge and, to date, no consensus has been reached for one single agent in second-line therapy. This article aims to review skin involvement as well as provide and update discussion on therapeutic options for both acute and chronic cutaneous GVHD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dermatopatias
/
Terapia de Imunossupressão
/
Transplante de Células-Tronco Hematopoéticas
/
Fármacos Dermatológicos
/
Doença Enxerto-Hospedeiro
Tipo de estudo:
Diagnostic_studies
Aspecto:
Patient_preference
Limite:
Humans
Idioma:
En
Revista:
Am J Clin Dermatol
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Nova Zelândia