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Mediators Go Together: High Production of CXCL9, CXCL10, IFN-γ, and TNF-α in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis.
Neco, Heytor Victor Pereira da Costa; Teixeira, Vanessa Gabryelle da Silva; da Trindade, Ana Carolina Lemos; Magalhães, Paula Machado Ribeiro; de Lorena, Virgínia Maria Barros; Castellano, Lúcio Roberto Cançado; de Souza, Joelma Rodrigues; Vasconcelos, Luydson Richardson; de Moura, Patrícia Muniz Mendes Freire; de Morais, Clarice Neuenschwander Lins.
Afiliação
  • Neco HVPDC; 1 Department of Virology and Experimental Therapy (LaViTE), Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz) , Recife, Brazil .
  • Teixeira VGDS; 2 Institute of Biological Sciences (ICB), University of Pernambuco , Recife, Brazil .
  • da Trindade ACL; 2 Institute of Biological Sciences (ICB), University of Pernambuco , Recife, Brazil .
  • Magalhães PMR; 3 Palliative Care Unit, Oswaldo Cruz University Hospital (HUOC) , Recife, Brazil .
  • de Lorena VMB; 4 Department of Immunology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz) , Recife, Brazil .
  • Castellano LRC; 5 Health Technical School, Federal University of Paraíba (UFPB) , João Pessoa, Brazil .
  • de Souza JR; 5 Health Technical School, Federal University of Paraíba (UFPB) , João Pessoa, Brazil .
  • Vasconcelos LR; 6 Department of Physiology and Pathology, Health Science Center, Federal University of Paraíba (UFPB) , João Pessoa, Brazil .
  • de Moura PMMF; 7 Department of Parasitology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz) , Recife, Brazil .
  • de Morais CNL; 2 Institute of Biological Sciences (ICB), University of Pernambuco , Recife, Brazil .
AIDS Res Hum Retroviruses ; 33(11): 1134-1139, 2017 Nov.
Article em En | MEDLINE | ID: mdl-28648091
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic demyelinating and disabling syndrome caused by human T lymphotropic virus 1 (HTLV-1). Although the pathogenic mechanisms that lead to HAM/TSP outcome have not been elucidated, genetic and immunological factors may be involved in the myelopathy occurrence. This study aimed to compare cytokines, chemokines, and nitric oxide (NO) levels in asymptomatic and HAM/TSP HTLV-1-infected patients. The study group consisted of 21 HAM/TSP and 48 asymptomatic HTLV-1 patients. Chemokines (CCL5, CCL2, CXCL8, CXCL9, and CXCL10) and cytokines [IL-2, interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), IL-4, IL-6, and IL-10] were measured using cytometric bead array, whereas NO production was measured after reaction of supernatants with nitrate reduction solution. CXCL9 and CXCL10 chemokines levels were found to be higher in the HAM/TSP group. CXCL9 was also strongly correlated with CXCL10 and both CXCL9 and CXCL10 were moderately correlated with CCL2 and CCL5 levels, in both HAM/TSP and asymptomatic groups. There was no significant difference related to NO, IL-4, IL-6, and IL-10 levels between the clinical groups but TNF-α and IFN-γ levels were increased in HAM/TSP patients. Thus, factors such as CXCL9, CXCL10, TNF-α, and IFN-γ could be good prognostic biomarker candidates, and further studies may help to clarify their association with HAM/TSP immunopathogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Infecções por HTLV-I / Citocinas / Óxido Nítrico Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: AIDS Res Hum Retroviruses Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Infecções por HTLV-I / Citocinas / Óxido Nítrico Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: AIDS Res Hum Retroviruses Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos