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Negative inotropism of terpenes on guinea pig left atrium: structure-activity relationships.
Vasconcelos, Carla M L; Oliveira, Ingrid S N; Santos, José N A; Souza, Américo A; Menezes-Filho, José E R; Silva Neto, Júlio A; Lima, Tamires C; de Sousa, Damião P.
Afiliação
  • Vasconcelos CML; a Department of Physiology , Federal University of Sergipe , São Cristóvão , Brazil.
  • Oliveira ISN; a Department of Physiology , Federal University of Sergipe , São Cristóvão , Brazil.
  • Santos JNA; a Department of Physiology , Federal University of Sergipe , São Cristóvão , Brazil.
  • Souza AA; a Department of Physiology , Federal University of Sergipe , São Cristóvão , Brazil.
  • Menezes-Filho JER; a Department of Physiology , Federal University of Sergipe , São Cristóvão , Brazil.
  • Silva Neto JA; a Department of Physiology , Federal University of Sergipe , São Cristóvão , Brazil.
  • Lima TC; b Department of Pharmacy , Federal University of Sergipe , São Cristóvão , Brazil.
  • de Sousa DP; c Department of Pharmaceutics Sciences , Federal University of Paraíba , João Pessoa , Brazil.
Nat Prod Res ; 32(12): 1428-1431, 2018 Jun.
Article em En | MEDLINE | ID: mdl-28641448
The aim of this work was to evaluate the pharmacological effect of seven structurally related terpenes on the contractility of cardiac muscle. The effect of terpenes was studied on isolated electrically driven guinea pig left atrium. From concentration-response curves for inotropic effect were determined the EC50 and relative potency of such terpenes. Our results revealed that all terpenes, except phytol, showed ability to reduce the contractile response of guinea pig left atrium. Further, relative potency was directly related to the number of isoprene units and to the lipophilicity of the compounds. For example, sesquiterpenes farnesol and nerolidol showed higher relative potency when compared with the monoterpenes citronellol, geraniol and nerol. We can conclude that most of the evaluated terpenes showed a promising negative inotropism on the atrial muscle. Future studies are necessary to investigate their action mechanism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relação Estrutura-Atividade / Terpenos / Fármacos Cardiovasculares / Átrios do Coração Limite: Animals Idioma: En Revista: Nat Prod Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relação Estrutura-Atividade / Terpenos / Fármacos Cardiovasculares / Átrios do Coração Limite: Animals Idioma: En Revista: Nat Prod Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido