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Effect of D-ribose-L-cysteine on aluminum induced testicular damage in male Sprague-Dawley rats.
Falana, Benedict; Adeleke, Opeyemi; Orenolu, Mulikat; Osinubi, Abraham; Oyewopo, Adeoye.
Afiliação
  • Falana B; Department of Anatomy, College of Health Sciences, Osun State University, Osogbo, Nigeria.
  • Adeleke O; Department of Anatomy, College of Health Sciences, Osun State University, Osogbo, Nigeria.
  • Orenolu M; Department of Anatomy, College of Health Sciences, Osun State University, Osogbo, Nigeria.
  • Osinubi A; Department of Anatomy, College of Medicine, University of Lagos, Lagos State, Nigeria.
  • Oyewopo A; Department of Anatomy, College of Health Sciences, University of Ilorin, Ilorin State, Nigeria.
JBRA Assist Reprod ; 21(2): 94-100, 2017 06 01.
Article em En | MEDLINE | ID: mdl-28609275
OBJECTIVE: This study investigated the effects of D-ribose and L-cysteine on aluminum-induced testicular damage in male Sprague-Dawley rats. METHOD: A total number of thirty-five (35) adult male Sprague-Dawley rats were divided into four groups (AD). Group A (comprised five (5) rats) was designated the Control Group that received Physiological Saline; while groups B, C, and D (comprised ten (10) rats) were given 75 mg/kg, 150 mg/kg and 300 mg/kg of body weight of aluminum chloride respectively for 39 days. At day 40, the aluminum-treated groups were subdivided into sub-groups (B1, C1, D1) comprising of five (5) rats each, and 30 mg/kg body weight of Riboceine were administered for twenty (20) days. Groups B, C and D remained on the normal dosage of aluminum chloride for three more weeks (59 days). RESULTS: Andrological parameters (Sperm count, motility, morphology and testosterone) in the aluminum-treated Groups B and C showed no significant difference in their mean values when compared with their control counterparts, whereas there was a significant reduction in the andrological parameters in Group D rats when compared with the Control animals. Histoarchitecture of the testes "stain with H&E" of Group A, B and C rats appeared normal while Group D rats showed testicular damages with several abnormal seminiferous tubules with incomplete maturation of germinal cell layers and absence of spermatozoa in their lumen; Leydig cells appear hyperplastic. Group B1, C1 and D1 andrological and histological parameters appeared normal. CONCLUSION: Riboceine treatment significantly attenuates aluminum-induced testicular toxicity in male Sprague-Dawley in rats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Testiculares / Testículo / Cisteína / Tiazolidinas / Alumínio Limite: Animals Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Nigéria País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Testiculares / Testículo / Cisteína / Tiazolidinas / Alumínio Limite: Animals Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Nigéria País de publicação: Brasil