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Topical treatment with nanoliposomal Amphotericin B reduces early lesion growth but fails to induce cure in an experimental model of cutaneous leishmaniasis caused by Leishmania mexicana.
Varikuti, Sanjay; Oghumu, Steve; Saljoughian, Noushin; Pioso, Marissa S; Sedmak, Bren E; Khamesipour, Ali; Satoskar, Abhay R.
Afiliação
  • Varikuti S; Department of Pathology, The Ohio State University Medical Center, Columbus, OH, USA.
  • Oghumu S; College of Public Health, The Ohio State University, Columbus, OH, USA.
  • Saljoughian N; Department of Pathology, The Ohio State University Medical Center, Columbus, OH, USA.
  • Pioso MS; Department of Pathology, The Ohio State University Medical Center, Columbus, OH, USA.
  • Sedmak BE; Department of Pathology, The Ohio State University Medical Center, Columbus, OH, USA.
  • Khamesipour A; Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences, Tehran, Iran.
  • Satoskar AR; Department of Pathology, The Ohio State University Medical Center, Columbus, OH, USA; Department of Microbiology, The Ohio State University, Columbus, OH, USA. Electronic address: abhay.satoskar@osumc.edu.
Acta Trop ; 173: 102-108, 2017 Sep.
Article em En | MEDLINE | ID: mdl-28602835
Leishmania mexicana infection causes localized skin lesions that can lead to tissue damage and permanent disfigurement if not resolved. Currently, recommended treatments include intravenous administration of Amphotericin B, which is undesirable due to the associated cost and patient burden related to receiving regular injections. In this study, we evaluated the effect of topical treatment with a nanoliposomal formulation of Amphotericin B that is penetrable to the skin (SinaAmphoLeish 0.4%) in mice infected with L. mexicana by using ulcerated (BALB/c) and non-ulcerated (129SVE) models. BALB/c mice received a 4 week treatment following ulcerated lesion development, while 129SVE mice received a 10 week treatment beginning at week 5 post-infection. Although mice from both models showed comparable susceptibility to L. mexicana infection after topical treatment with SinaAmphoLeish relative to controls, 129SVE mice displayed a transient decrease in lesion sizes which eventually became similar to control mice. On other hand this treatment resulted in no reduction in the lesion sizes in BALB/c mice. 129SVE treated mice exhibited greater IFN-γ, IL-4, and IL-10 cytokine levels and higher T-cell proliferation in re-stimulated draining lymph node cells. BALB/c mice showed no differences in cytokine responses between treated and control mice. These findings indicate that topical SinaAmphoLeish treatment is not likely to be effective in the treatment of cutaneous leishmaniasis caused by L. mexicana.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leishmania mexicana / Anfotericina B / Leishmaniose Cutânea / Nanoestruturas Tipo de estudo: Prognostic_studies Limite: Animals País/Região como assunto: Mexico Idioma: En Revista: Acta Trop Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leishmania mexicana / Anfotericina B / Leishmaniose Cutânea / Nanoestruturas Tipo de estudo: Prognostic_studies Limite: Animals País/Região como assunto: Mexico Idioma: En Revista: Acta Trop Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda