Cyclooxygenase-2 inhibitors differentially attenuate pentylenetetrazol-induced seizures and increase of pro- and anti-inflammatory cytokine levels in the cerebral cortex and hippocampus of mice.

Temp, Fernanda Rossatto; Marafiga, Joseane Righes; Milanesi, Laura Hautrive; Duarte, Thiago; Rambo, Leonardo Magno; Pillat, Micheli Mainardi; Mello, Carlos Fernando

Temp, Fernanda Rossatto; Marafiga, Joseane Righes; Milanesi, Laura Hautrive; Duarte, Thiago; Rambo, Leonardo Magno; Pillat, Micheli Mainardi; Mello, Carlos Fernando.

Afiliação

Temp FR; Graduation Program in Pharmacology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil.
Marafiga JR; Graduation Program in Pharmacology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil.
Milanesi LH; Graduation Program in Pharmacology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil.
Duarte T; Graduation Program in Pharmacology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil; Center of Health Sciences, Lutheran University of Brazil, Santa Maria, RS 97020-001, Brazil.
Rambo LM; Department of Physical Education, Federal University of Pampa - UNIPAMPA, Uruguaiana, RS 97508-000, Brazil.
Pillat MM; Department of Physiology and Pharmacology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil; Department of Biochemistry, Institute of Chemistry, University of São Paulo, Brazil.
Mello CF; Graduation Program in Pharmacology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil; Department of Physiology and Pharmacology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil. Electronic address: cf.mell

Eur J Pharmacol ; 810: 15-25, 2017 Sep 05.

Article em En | MEDLINE | ID: mdl-28583427

Assuntos

Córtex Cerebral/efeitos dos fármacos; Inibidores de Ciclo-Oxigenase 2/farmacologia; Citocinas/metabolismo; Hipocampo/efeitos dos fármacos; Pentilenotetrazol/efeitos adversos; Convulsões/tratamento farmacológico; Convulsões/metabolismo; Animais; Córtex Cerebral/metabolismo; Inibidores de Ciclo-Oxigenase 2/uso terapêutico; Hipocampo/metabolismo; Inflamação/metabolismo; Masculino; Camundongos; Convulsões/induzido quimicamente

Palavras-chave

Carboxymethylcellulose (PubChem CID: 23706213); Celecoxib; Celecoxib (PubChem CID: 2662); Cytokines; Epilepsy; Ethylenediaminetetraacetic acid (PubChem CID: 6049); Etoricoxib; Etoricoxib (PubChem CID: 123619); Neuroinflammation; Nimesulide; Nimesulide (PubChem CID: 4495); Pentylenetetrazol (PubChem CID: 5917); Phenylmethylsulfonyl fluoride (PubChem CID: 4784); Phosphate-buffered saline (PBS) (PubChem CID: 24978514); Sodium Chloride (PubChem CID: 5234); Tween 80 (PubChem CID: 443315)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pentilenotetrazol / Convulsões / Córtex Cerebral / Citocinas / Inibidores de Ciclo-Oxigenase 2 / Hipocampo Limite: Animals Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda

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