Early biochemical effects of an organic mercury fungicide on infants: "dose makes the poison".
Science
; 227(4687): 638-40, 1985 Feb 08.
Article
em En
| MEDLINE
| ID: mdl-2857500
Phenylmercury absorbed through the skin from contaminated diapers affected urinary excretion in infants in Buenos Aires. The effects were reversible and quantitatively related to the concentration of urinary mercury. Excretion of gamma-glutamyl transpeptidase, an enzyme in the brush borders of renal tubular cells, increased in a dose-dependent manner when mercury excretion exceeded a "threshold" value. Urine volume also increased but at a higher threshold with respect to mercury. The results support the threshold concept of the systemic toxicity of metals. gamma-Glutamyl transpeptidase is a useful and sensitive marker for preclinical effects of toxic metals.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Fenilmercúrio
/
Fungicidas Industriais
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Animals
/
Humans
/
Infant
País/Região como assunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Science
Ano de publicação:
1985
Tipo de documento:
Article
País de publicação:
Estados Unidos