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Evaluation of antioxidant therapy in experimental Chagas disease.
Tieghi, Thais de Mello; Manca, Camilla Chimelo; Garcia, Lígia Cangussu Tomaz; Castanho, Roberto Esteves Pires; Therezo, Altino Luiz Silva; Frei, Fernando; Taipeiro, Elane de Fátima; Martins, Luciamáre Perinetti Alves.
Afiliação
  • Tieghi TM; Disciplina de Parasitolgia, Faculdade de Medicina de Marília, Marília, SP, Brasil.
  • Manca CC; Disciplina de Parasitolgia, Faculdade de Medicina de Marília, Marília, SP, Brasil.
  • Garcia LCT; Disciplina de Parasitolgia, Faculdade de Medicina de Marília, Marília, SP, Brasil.
  • Castanho REP; Disciplina de Parasitolgia, Faculdade de Medicina de Marília, Marília, SP, Brasil.
  • Therezo ALS; Disciplina de Anatomia Patológica, Faculdade de Medicina de Marília, Marília, SP, Brasil.
  • Frei F; Departamento de Biologia, Universidade Estadual Paulista, Assis, SP, Brasil.
  • Taipeiro EF; Disciplina de Bioquímica, da Faculdade de Medicina de Marília, Marília, SP, Brasil.
  • Martins LPA; Disciplina de Parasitolgia, Faculdade de Medicina de Marília, Marília, SP, Brasil.
Rev Soc Bras Med Trop ; 50(2): 184-193, 2017.
Article em En | MEDLINE | ID: mdl-28562754
INTRODUCTION:: Stimulation of inflammatory mediators such as cytokines and chemokines may cause oxidative stress in Chagas disease. In this study, we evaluated the merit of vitamins C and E as antioxidant therapy to minimize the oxidative stress-induced damage in an experimental model of Chagas disease. METHODS:: Ninety-six Swiss mice were infected with Trypanosoma cruzi QM2 and treated with vitamins C, E, or both (C/E) for 60 and 120 days, and their effects compared to placebo administration were evaluated in the acute and chronic disease phases. RESULTS:: There was no difference in parasitemia among treatment groups. However, histological analysis showed more severe inflammation in the skeletal muscle in the vitamin supplementation groups at both the acute and chronic phases. Biochemical analyses during the acute phase showed increased ferric-reducing ability of plasma (FRAP) and glutathione (GSH) levels in the vitamin C and C/E groups. In the chronic phase, a decrease in GSH levels was observed in the vitamin E group and a decrease in thiobarbituric acid reactive substances (TBARS) was observed in the vitamin C/E group. Moreover, there was a decrease in TBARS in the cardiac tissues of the vitamin C and C/E groups compared to that of the placebo group, although this level was greater in the vitamin E group than in the vitamin C group. CONCLUSIONS:: The antioxidant action of vitamins C and E reduced oxidative stress in both the acute and chronic phases of Chagas disease, with a marked effect from joint administration, indicating their inherent synergism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Ascórbico / Vitamina E / Doença de Chagas / Estresse Oxidativo / Antioxidantes Limite: Animals Idioma: En Revista: Rev Soc Bras Med Trop Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Ascórbico / Vitamina E / Doença de Chagas / Estresse Oxidativo / Antioxidantes Limite: Animals Idioma: En Revista: Rev Soc Bras Med Trop Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil