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Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer.
Zhang, Y; Chen, Q.
Afiliação
  • Zhang Y; Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
  • Chen Q; Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
Braz J Med Biol Res ; 50(6): e6104, 2017 May 18.
Article em En | MEDLINE | ID: mdl-28538838
Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many researchers have suggested that matrix metalloproteinases (MMPs) have remarkably high expression in ovarian cancer tissues. MMPs are considered to be related to the occurrence, development, invasion and metastasis of ovarian cancer. Moreover, some studies have discovered that the unbalance between MMPs and tissue inhibitor of metalloproteinases (TIMPs) are associated with the malignant phenotype of tumors. This review summarizes the latest research progress of MMPs in ovarian cancer. The investigation of MMP mechanism in ovarian cancer will facilitate the development of effective anti-tumor drugs, and thereby improve the survival rate of patients with ovarian cancer.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Biomarcadores Tumorais / Metaloproteinases da Matriz Limite: Female / Humans Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Biomarcadores Tumorais / Metaloproteinases da Matriz Limite: Female / Humans Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Brasil