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Neuroleptic-Induced Parkinsonism in Elderly Patients Diagnosed With Psychotic Major Depression and Dementia of the Alzheimer Type.
Sweet, Robert A; Mulsant, Benoit H; Pollock, Bruce G; Rosen, Jules; Altieri, Linda P.
Afiliação
  • Sweet RA; Departments of Psychiatry and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
  • Mulsant BH; Departments of Psychiatry and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
  • Pollock BG; Departments of Psychiatry and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
  • Rosen J; Departments of Psychiatry and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
  • Altieri LP; Departments of Psychiatry and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Am J Geriatr Psychiatry ; 4(4): 311-319, 1996.
Article em En | MEDLINE | ID: mdl-28530968
The authors prospectively examined elderly patients diagnosed with major depression with psychotic features (MD-P) and patients diagnosed with dementia of the Alzheimer Type (DAT) for neuroleptic-induced parkinsonism (NIP) during perphenazine treatment. Baseline parkinsonian symptoms did not differ between groups. With treatment, mean NIP score doubled in DAT patients but remained unchanged in the MD-P group. The difference between groups was highly significant and remained so after the effects of age, perphenazine dose, and duration of perphenazine treatment were controlled. Although the mechanisms underlying these differences in NIP development remain to be determined, clinical guidelines for neuroleptic dosages in elderly patients need to account for variability in neuroleptic tolerance between diagnostic groups.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Guideline Idioma: En Revista: Am J Geriatr Psychiatry Assunto da revista: GERIATRIA / PSIQUIATRIA Ano de publicação: 1996 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Guideline Idioma: En Revista: Am J Geriatr Psychiatry Assunto da revista: GERIATRIA / PSIQUIATRIA Ano de publicação: 1996 Tipo de documento: Article País de publicação: Reino Unido