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Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children.
Farook, Vidya S; Reddivari, Lavanya; Mummidi, Srinivas; Puppala, Sobha; Arya, Rector; Lopez-Alvarenga, Juan Carlos; Fowler, Sharon P; Chittoor, Geetha; Resendez, Roy G; Kumar, Birunda Mohan; Comuzzie, Anthony G; Curran, Joanne E; Lehman, Donna M; Jenkinson, Christopher P; Lynch, Jane L; DeFronzo, Ralph A; Blangero, John; Hale, Daniel E; Duggirala, Ravindranath; Vanamala, Jairam Kp.
Afiliação
  • Farook VS; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX; Departments of.
  • Reddivari L; Plant Science and.
  • Mummidi S; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX; Departments of.
  • Puppala S; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX; Departments of.
  • Arya R; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX; Departments of.
  • Lopez-Alvarenga JC; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX; Departments of.
  • Fowler SP; Medicine and.
  • Chittoor G; Department of Nutrition, University of North Carolina at Chapel Hill, Kannapolis, NC; and.
  • Resendez RG; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX; Departments of.
  • Kumar BM; Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO.
  • Comuzzie AG; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX; Departments of.
  • Curran JE; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX; Departments of.
  • Lehman DM; Medicine and.
  • Jenkinson CP; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX; Departments of.
  • Lynch JL; Pediatrics, University of Texas Health San Antonio, San Antonio, TX.
  • DeFronzo RA; Medicine and.
  • Blangero J; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX; Departments of.
  • Hale DE; Pediatrics, University of Texas Health San Antonio, San Antonio, TX.
  • Duggirala R; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX; Departments of juv4@psu.edu ravindranath.duggirala@utrgv.edu.
  • Vanamala JK; Food Science and juv4@psu.edu ravindranath.duggirala@utrgv.edu.
Am J Clin Nutr ; 106(1): 52-58, 2017 Jul.
Article em En | MEDLINE | ID: mdl-28515064
Background: Dietary intake of phytonutrients present in fruits and vegetables, such as carotenoids, is associated with a lower risk of obesity and related traits, but the impact of genetic variation on these associations is poorly understood, especially in children.Objective: We estimated common genetic influences on serum carotenoid concentrations and obesity-related traits in Mexican American (MA) children.Design: Obesity-related data were obtained from 670 nondiabetic MA children, aged 6-17 y. Serum α- and ß-carotenoid concentrations were measured in ∼570 (α-carotene in 565 and ß-carotene in 572) of these children with the use of an ultraperformance liquid chromatography-photodiode array. We determined heritabilities for both carotenoids and examined their genetic relation with 10 obesity-related traits [body mass index (BMI), waist circumference (WC), high-density lipoprotein (HDL) cholesterol, triglycerides, fat mass (FM), systolic and diastolic blood pressure, fasting insulin and glucose, and homeostasis model assessment of insulin resistance] by using family data and a variance components approach. For these analyses, carotenoid values were inverse normalized, and all traits were adjusted for significant covariate effects of age and sex.Results: Carotenoid concentrations were highly heritable and significant [α-carotene: heritability (h2) = 0.81, P = 6.7 × 10-11; ß-carotene: h2 = 0.90, P = 3.5 × 10-15]. After adjusting for multiple comparisons, we found significant (P ≤ 0.05) negative phenotypic correlations between carotenoid concentrations and the following traits: BMI, WC, FM, and triglycerides (range: α-carotene = -0.19 to -0.12; ß-carotene = -0.24 to -0.13) and positive correlations with HDL cholesterol (α-carotene = 0.17; ß-carotene = 0.24). However, when the phenotypic correlations were partitioned into genetic and environmental correlations, we found marginally significant (P = 0.051) genetic correlations only between ß-carotene and BMI (-0.27), WC (-0.30), and HDL cholesterol (0.31) after accounting for multiple comparisons. None of the environmental correlations were significant.Conclusions: The findings from this study suggest that the serum carotenoid concentrations were under strong additive genetic influences based on variance components analyses, and that the common genetic factors may influence ß-carotene and obesity and lipid traits in MA children.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenótipo / Carotenoides / Estado Nutricional / Americanos Mexicanos / Beta Caroteno / Característica Quantitativa Herdável / Obesidade Tipo de estudo: Prognostic_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Am J Clin Nutr Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenótipo / Carotenoides / Estado Nutricional / Americanos Mexicanos / Beta Caroteno / Característica Quantitativa Herdável / Obesidade Tipo de estudo: Prognostic_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Am J Clin Nutr Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos