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Antibacterial Activity of 7-Epiclusianone and Its Novel Copper Metal Complex on Streptococcus spp. Isolated from Bovine Mastitis and Their Cytotoxicity in MAC-T Cells.
de Barros, Mariana; Perciano, Pedro Griffo; Dos Santos, Marcelo Henrique; De Oliveira, Leandro Licursi; Costa, Éderson D'Martin; Moreira, Maria Aparecida Scatamburlo.
Afiliação
  • de Barros M; Department of Veterinary, Universidade Federal de Viçosa, Viçosa 36570-900, Brazil. mariana.barros@ufv.br.
  • Dos Santos MH; Department of Chemistry, Universidade Federal de Viçosa, Viçosa 36570-900, Brazil. marcelo_hs@yahoo.com.br.
  • De Oliveira LL; Department of General Biology, Universidade Federal de Viçosa, Viçosa 36570-900, Brazil. leandro.licursi@ufv.br.
  • Costa ÉD; Institute of Chemistry, Universidade Federal de Alfenas, Alfenas 37130-000, Brazil. edm_quimica@yahoo.com.br.
  • Moreira MAS; Department of Veterinary, Universidade Federal de Viçosa, Viçosa 36570-900, Brazil. masm@ufv.br.
Molecules ; 22(5)2017 May 17.
Article em En | MEDLINE | ID: mdl-28513553
Mastitis is an inflammation of mammary gland parenchyma that adversely affects bovine health and dairy production worldwide despite significant efforts to eradicate it. The aim of this work was to characterize the antimicrobial activity of 7-epiclusianone (7-epi), a compound extracted from the Rheedia brasiliensis fruit, its complex with copper against Streptococcus spp. isolated from bovine mastitis, and to assess their cytotoxicity to bovine mammary alveolar cells (MAC-T). The complex 7-epiclusianone-Cu (7-epi-Cu) was an amorphous green solid with optical activity. Its vibrational spectrum in the infrared region showed absorption bands in the high-frequency region, as well as bands that can be attributed to the unconjugated and conjugated stretching of the free ligand. The complex was anhydrous. One of the tested bacterial strains was not sensitive to the compounds, while the other three had MIC values of 7.8 µg mL-1 and minimum bactericidal concentration (MBC) values between 15.6 and 31.3 µg mL-1. These two compounds are bacteriostatic, did not cause damage to the cell wall and, at sub-inhibitory concentrations, did not induce bacterial adhesion. The compounds were not cytotoxic. Based on these results, 7-epi and 7-epi-Cu exhibited desirable antimicrobial properties and could potentially be used in bovine mastitis treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptococcus / Benzofenonas / Benzoquinonas / Glândulas Mamárias Animais / Mastite Bovina / Antibacterianos Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptococcus / Benzofenonas / Benzoquinonas / Glândulas Mamárias Animais / Mastite Bovina / Antibacterianos Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça