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Polyelectrolyte complexes based on alginate/tanfloc: Optimization, characterization and medical application.
Facchi, Débora P; Lima, Ana C; de Oliveira, Jean H; Lazarin-Bidóia, Danielle; Nakamura, Celso V; Canesin, Edmilson A; Bonafé, Elton G; Monteiro, Johny P; Visentainer, Jesuí V; Muniz, Edvani C; Martins, Alessandro F.
Afiliação
  • Facchi DP; Postgraduate Program in Environmental Engineering (PPGEA), Federal University of Technology - Paraná (UTFPR-AP), CEP 86812-460 Apucarana, PR, Brazil; Federal University of Technology - Paraná (UTFPR-AP), CEP 86812-460 Apucarana, PR, Brazil.
  • Lima AC; Federal University of Technology - Paraná (UTFPR-AP), CEP 86812-460 Apucarana, PR, Brazil.
  • de Oliveira JH; Department of Chemistry, State University of Maringá (UEM), Av. Colombo 5790, CEP 87020-900 Maringá, PR, Brazil.
  • Lazarin-Bidóia D; Applied Microbiology Laboratory to Natural and Synthetic Products and Technological Innovation Laboratory in Drugs and Cosmetics Development, Av. Colombo, 5790, 87020-900, Maringá, PR, Brazil.
  • Nakamura CV; Applied Microbiology Laboratory to Natural and Synthetic Products and Technological Innovation Laboratory in Drugs and Cosmetics Development, Av. Colombo, 5790, 87020-900, Maringá, PR, Brazil.
  • Canesin EA; Federal University of Technology - Paraná (UTFPR-AP), CEP 86812-460 Apucarana, PR, Brazil.
  • Bonafé EG; Federal University of Technology - Paraná (UTFPR-AP), CEP 86812-460 Apucarana, PR, Brazil.
  • Monteiro JP; Federal University of Technology - Paraná (UTFPR-AP), CEP 86812-460 Apucarana, PR, Brazil; Postgraduate Program in Materials Science & Engineering (PPGCEM), Federal University of Technology - Paraná (UTFPR-LD), CEP 86036-370 Londrina, PR, Brazil.
  • Visentainer JV; Department of Chemistry, State University of Maringá (UEM), Av. Colombo 5790, CEP 87020-900 Maringá, PR, Brazil.
  • Muniz EC; Postgraduate Program in Materials Science & Engineering (PPGCEM), Federal University of Technology - Paraná (UTFPR-LD), CEP 86036-370 Londrina, PR, Brazil; Polymers and Composite Materials Group (GMPC), Department of Chemistry, State University of Maringá (UEM), Av. Colombo 5790, CEP 87020-900 M
  • Martins AF; Postgraduate Program in Environmental Engineering (PPGEA), Federal University of Technology - Paraná (UTFPR-AP), CEP 86812-460 Apucarana, PR, Brazil; Federal University of Technology - Paraná (UTFPR-AP), CEP 86812-460 Apucarana, PR, Brazil; Postgraduate Program in Materials Science & Engineering
Int J Biol Macromol ; 103: 129-138, 2017 Oct.
Article em En | MEDLINE | ID: mdl-28501603
Hydrogels based on alginate and tanfloc (a cationic biopolymer obtained from natural condensed tannins) were successfully prepared. Tanfloc (TN) presents high aqueous solubility at pHs lower than 10; it contains substituted amino sites and molar weight of ca. 600,000gmol-1. A factorial design (22) was used to optimize the yield of alginate/tanfloc polyelectrolyte complexes (PECs). Dialysis recovered the overplus of alginate (AG) no complexed with TN. These materials were characterized by thermal analyses (TGA/DTG and DSC), zeta potential, and FTIR, while SEM technique depicted a rough surface on AG/TN complex, containing non-homogeneous pores. Indeed, the AG and TN were tailored to elicit scaffold materials with outstanding cytocompatibility, mainly upon mouse preosteoblastic cells because of reconstruction of bone tissues (119% at 10days). The AG/TN complex also displayed antioxidant and bactericidal activities against Staphylococcus aureus (S. aureus). Besides, the pristine TN fostered bacteriostatic and bactericidal performances towards S. aureus and Escherichia coli. However, for our best knowledge, no studies were still carried out on TN and TN-based materials for medical purpose.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Taninos / Alginatos / Polieletrólitos / Antibacterianos Limite: Animals Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Taninos / Alginatos / Polieletrólitos / Antibacterianos Limite: Animals Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda