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Human islet xenotransplantation in rodents: A literature review of experimental model trends.
Iuamoto, Leandro Ryuchi; Franco, André Silva; Suguita, Fábio Yuji; Essu, Felipe Futema; Oliveira, Lucas Torres; Kato, Juliana Mika; Torsani, Matheus Belloni; Meyer, Alberto; Andraus, Wellington; Chaib, Eleazar; D'Albuquerque, Luiz Augusto Carneiro.
Afiliação
  • Iuamoto LR; Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Franco AS; Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Suguita FY; Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Essu FF; Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Oliveira LT; Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Kato JM; Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Torsani MB; Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Meyer A; Departamento de Gastroenterologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Andraus W; Departamento de Gastroenterologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Chaib E; Departamento de Gastroenterologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • D'Albuquerque LAC; Departamento de Gastroenterologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
Clinics (Sao Paulo) ; 72(4): 238-243, 2017 Apr.
Article em En | MEDLINE | ID: mdl-28492724
Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low number of pancreases that are available for transplantation. Rodent models have been chosen in most studies of islet rejection and type 1 diabetes prevention to evaluate the quality and function of isolated human islets and to identify alternative solutions to the problem of islet scarcity. The purpose of this study is to conduct a review of islet xenotransplantation experiments from humans to rodents, to organize and analyze the parameters of these experiments, to describe trends in experimental modeling and to assess the viability of this procedure. In this study, we reviewed recently published research regarding islet xenotransplantation from humans to rodents, and we summarized the findings and organized the relevant data. The included studies were recent reports that involved xenotransplantation using human islets in a rodent model. We excluded the studies that related to isotransplantation, autotransplantation and allotransplantation. A total of 34 studies that related to xenotransplantation were selected for review based on their relevance and current data. Advances in the use of different graft sites may overcome autoimmunity and rejection after transplantation, which may solve the problem of the scarcity of islet donors in patients with type 1 diabetes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante Heterólogo / Transplante das Ilhotas Pancreáticas / Modelos Animais / Diabetes Mellitus Experimental Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Animals / Humans Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante Heterólogo / Transplante das Ilhotas Pancreáticas / Modelos Animais / Diabetes Mellitus Experimental Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Animals / Humans Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos