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Eutirucallin: A Lectin with Antitumor and Antimicrobial Properties.
Palharini, Julio G; Richter, Aline C; Silva, Mariana F; Ferreira, Flavia B; Pirovani, Carlos P; Naves, Karinne S C; Goulart, Vivian A; Mineo, Tiago W P; Silva, Marcelo J B; Santiago, Fernanda M.
Afiliação
  • Palharini JG; Laboratory of Immunoparasitology "Dr. Mario Endsfeldz Camargo", Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil.
  • Richter AC; Laboratory of Immunoparasitology "Dr. Mario Endsfeldz Camargo", Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil.
  • Silva MF; Laboratory of Immunoparasitology "Dr. Mario Endsfeldz Camargo", Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil.
  • Ferreira FB; Laboratory of Immunoparasitology "Dr. Mario Endsfeldz Camargo", Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil.
  • Pirovani CP; Biological Sciences Department, State University of Santa CruzIlhéus, Brazil.
  • Naves KSC; Laboratory of Clinical Bacteriology, Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil.
  • Goulart VA; Laboratory of Nanobiotechnology, Institute of Genetics and Biochemistry, Federal University of UberlândiaUberlândia, Brazil.
  • Mineo TWP; Laboratory of Immunoparasitology "Dr. Mario Endsfeldz Camargo", Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil.
  • Silva MJB; Laboratory of Tumor Biomarkers and Osteoimmunology, Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil.
  • Santiago FM; Laboratory of Immunoparasitology "Dr. Mario Endsfeldz Camargo", Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil.
Front Cell Infect Microbiol ; 7: 136, 2017.
Article em En | MEDLINE | ID: mdl-28487845
Eutirucallin is a lectin isolated from the latex of Euphorbia tirucalli, a plant known for its medical properties. The present study explores various characteristics of Eutirucallin including stability, cytotoxicity against tumor cells, antimicrobial and antiparasitic activities. Eutirucallin was stable from 2 to 40 days at 4°C, maintained hemagglutinating activity within a restricted range, and showed optimal activity at pH 7.0-8.0. Eutirucallin presented antiproliferative activity for HeLa, PC3, MDA-MB-231, and MCF-7 tumor cells but was not cytotoxic for non-tumorigenic cells such as macrophages and fibroblasts. Eutirucallin inhibited the Ehrlich ascites carcinoma in vivo and it was also observed that Eutirucallin inhibited 62.5% of Escherichia coli growth. Also, Eutirucallin showed to be effective when tested directly against Toxoplasma gondii infection in vitro. Therefore, this study sheds perspectives for pharmacological applications of Eutirucallin.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Lectinas de Plantas / Anti-Infecciosos / Antineoplásicos Limite: Animals / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Front Cell Infect Microbiol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Lectinas de Plantas / Anti-Infecciosos / Antineoplásicos Limite: Animals / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Front Cell Infect Microbiol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça