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Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review.
Ribeiro, Daniel Araki; Yujra, Veronica Quispe; da Silva, Victor Hugo Pereira; Claudio, Samuel Rangel; Estadella, Debora; de Barros Viana, Milena; Oshima, Celina Tizuko Fujiyama.
Afiliação
  • Ribeiro DA; Department of Pathology, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil. daribeiro@unifesp.br.
  • Yujra VQ; Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil. daribeiro@unifesp.br.
  • da Silva VHP; Departamento de Biociências, Universidade Federal de São Paulo, UNIFESP, Av. Ana Costa, 95, Vila Mathias, Santos, SP, 11060-001, Brazil. daribeiro@unifesp.br.
  • Claudio SR; Department of Pathology, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
  • Estadella D; Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
  • de Barros Viana M; Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
  • Oshima CTF; Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
Environ Sci Pollut Res Int ; 24(18): 15254-15259, 2017 Jun.
Article em En | MEDLINE | ID: mdl-28477256
Genotoxicity is the ability of an agent to produce damage on the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, to elucidate the putative mechanisms of genotoxicity induced by fluoride are important to measure the degree of risk involved to human populations. The purpose of this article is to provide a comprehensive review on genotoxicity induced by fluoride on the basis of its mechanisms of action. In the last 10 years, all published data showed some evidence related to genotoxicity, which is due to mitochondrial disruption, oxidative stress, and cell cycle disturbances. However, this is an area that still requires a lot of investigation since the published data are not sufficient for clarifying the genotoxicity induced by fluoride. Certainly, the new information will be added to those already established for regulatory purposes as a safe way to promote oral healthcare and prevent oral carcinogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Fluoretos / Mutagênicos Limite: Humans Idioma: En Revista: Environ Sci Pollut Res Int Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Fluoretos / Mutagênicos Limite: Humans Idioma: En Revista: Environ Sci Pollut Res Int Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha