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Interstitial PDT using diffuser fiber-investigation in phantom and in vivo models.
Stringasci, Mirian D; Fortunato, Thereza C; Moriyama, Lilian T; Filho, José Dirceu Vollet; Bagnato, Vanderlei S; Kurachi, Cristina.
Afiliação
  • Stringasci MD; Sao Carlos Institute of Physics, University of São Paulo, Trabalhador Sao-Carlense Street, Number 400, São Carlos, São Paulo, CEP: 13566-590, Brazil. mirianstringasci@gmail.com.
  • Fortunato TC; Sao Carlos Institute of Physics, University of São Paulo, Trabalhador Sao-Carlense Street, Number 400, São Carlos, São Paulo, CEP: 13566-590, Brazil.
  • Moriyama LT; Sao Carlos Institute of Physics, University of São Paulo, Trabalhador Sao-Carlense Street, Number 400, São Carlos, São Paulo, CEP: 13566-590, Brazil.
  • Filho JDV; Sao Carlos Institute of Physics, University of São Paulo, Trabalhador Sao-Carlense Street, Number 400, São Carlos, São Paulo, CEP: 13566-590, Brazil.
  • Bagnato VS; Sao Carlos Institute of Physics, University of São Paulo, Trabalhador Sao-Carlense Street, Number 400, São Carlos, São Paulo, CEP: 13566-590, Brazil.
  • Kurachi C; Sao Carlos Institute of Physics, University of São Paulo, Trabalhador Sao-Carlense Street, Number 400, São Carlos, São Paulo, CEP: 13566-590, Brazil.
Lasers Med Sci ; 32(5): 1009-1016, 2017 Jul.
Article em En | MEDLINE | ID: mdl-28474212
Photodynamic therapy (PDT) has been used for local treatment of several types of tumors. Light penetration of biological tissue is one limiting factor in PDT, decreasing the success rates of the treatment of invasive and solid tumors. In those cases, a possible solution is to use interstitial PDT, in which both diffuser optical fibers are inserted into the tumor. The uniformity of the diffuser emission plays a crucial role in planning the delivery of the appropriate light fluence and in ensuring treatment success. In this study, we characterized a diffuser optical fiber concerning its homogeneity. We showed that the diffuser emission can be inhomogeneous and that the necrosis generated by interstitial PDT using such a diffuser for illumination is asymmetrical in volume as a result. This observation has relevant consequences in achieving success in PDT and phototherapies in general, as the delivered light fluence depends on adequate previous knowledge of the irradiation profile.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Imagens de Fantasmas / Fibras Ópticas / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Lasers Med Sci Assunto da revista: BIOTECNOLOGIA / RADIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Imagens de Fantasmas / Fibras Ópticas / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Lasers Med Sci Assunto da revista: BIOTECNOLOGIA / RADIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido