Relationship between the risk factors for human papillomavirus infection and lower genital tract precursor lesion and cancer development in female transplant recipients.

de Oliveira Martins, Caroline Alves; Do Val Guimarães, Isabel Cristina Chulvis; Velarde, Luis Guillermo Coca

de Oliveira Martins, Caroline Alves; Do Val Guimarães, Isabel Cristina Chulvis; Velarde, Luis Guillermo Coca.

Afiliação

de Oliveira Martins CA; Department of Obstetrics and Gynecology, Hospital Federal de Bonsucesso, Rio de Janeiro, Rio de Janeiro, Brazil.
Do Val Guimarães ICC; Obstetrics and Gynecology Department, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.
Velarde LGC; Statistics Department, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.

Transpl Infect Dis ; 19(4)2017 Aug.

Article em En | MEDLINE | ID: mdl-28456141

RESUMO

BACKGROUND: This study aimed to analyze the relationship between the several risk factors for human papillomavirus (HPV) infection and its persistence and to assess the prevalence of the lower genital tract precursor lesions, cancer, and HPV infection in female transplant recipients, besides the most prevalent HPV types. METHODS: The methodology adopted was a cross-sectional study with a random sample of 61 patients. RESULTS: The results indicated 10 cases (16.4%) of lesions, 54.5% of the overall prevalence of HPV infection, and HPV 16 was the most common high-risk HPV type, followed by HPV 51/53/70. A multiple logistic regression was done and hormone use presented a statistically significant association with high-risk HPV infection (P=.037). No statistically significant association was identified for the set of all factors with the lesions studied. CONCLUSIONS: The high prevalence of HPV infection and its precursor lesions confirmed the importance of differential screening and follow-up of transplanted patients. Condom use must be encouraged. The study result also confirmed the importance of knowledge of the viral type, in order to analyze the impact of HPV immunization, particularly against HPV types that are not 16/18. The reasonable rate of other genotypes, besides the vaccine types, should be considered to evaluate vaccination strategies.

Assuntos

Neoplasias/epidemiologia; Papillomaviridae/isolamento & purificação; Infecções por Papillomavirus/epidemiologia; Displasia do Colo do Útero/epidemiologia; Adulto; Idoso; Brasil/epidemiologia; Estudos Transversais; Feminino; Humanos; Pessoa de Meia-Idade; Neoplasias/complicações; Infecções por Papillomavirus/complicações; Infecções por Papillomavirus/virologia; Prevalência; Fatores de Risco; Transplantados; Displasia do Colo do Útero/complicações; Adulto Jovem

Palavras-chave

HPV; cervical intraepithelial neoplasia; human papillomavirus; transplants; uterine cervical dysplasia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Displasia do Colo do Útero / Infecções por Papillomavirus / Neoplasias Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Transpl Infect Dis Assunto da revista: TRANSPLANTE Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca

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