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Long-Term Intermittent Exposure to High Altitude Elevates Asymmetric Dimethylarginine in First Exposed Young Adults.
Lüneburg, Nicole; Siques, Patricia; Brito, Julio; De La Cruz, Juan José; León-Velarde, Fabiola; Hannemann, Juliane; Ibanez, Cristian; Böger, Rainer H.
Afiliação
  • Lüneburg N; 1 Department of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf , Hamburg, Germany .
  • Siques P; 2 Institute of Health Studies , Universidad Arturo Prat, Iquique, Chile .
  • Brito J; 2 Institute of Health Studies , Universidad Arturo Prat, Iquique, Chile .
  • De La Cruz JJ; 3 Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid , Madrid, Spain .
  • León-Velarde F; 4 Department of Biological and Physiological Sciences, Facultad de Ciencias y Filosofía/IIA, Universidad Peruana Cayetano Heredia , Lima, Perú .
  • Hannemann J; 1 Department of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf , Hamburg, Germany .
  • Ibanez C; 2 Institute of Health Studies , Universidad Arturo Prat, Iquique, Chile .
  • Böger RH; 1 Department of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf , Hamburg, Germany .
High Alt Med Biol ; 18(3): 226-233, 2017 Sep.
Article em En | MEDLINE | ID: mdl-28453332
Lüneburg, Nicole, Patricia Siques, Julio Brito, Juan José De La Cruz, Fabiola León-Velarde, Juliane Hannemann, Cristian Ibanez, and Rainer Böger. Long-term intermittent exposure to high altitude elevates asymmetric dimethylarginine in first exposed young adults. High Alt Med Biol. 18:226-233, 2017.-Hypoxia-induced dysregulation of pulmonary and cerebral circulation may be related to an impaired nitric oxide (NO) pathway. We investigated the effect of chronic intermittent hypobaric hypoxia (CIH) on metabolites of the NO pathway. We measured asymmetric and symmetric dimethylarginine (ADMA and SDMA) and monomethyl-L-arginine (L-NMMA) and assessed their associations with acclimatization in male draftees (n = 72) undergoing CIH shifts at altitude (3550 m) during 3 months. Sixteen Andean natives living at altitude (3675 m) (chronic hypobaric hypoxia [CH]) were included for comparison. In CIH, ADMA and L-NMMA plasma concentrations increased from 1.14 ± 0.04 to 1.95 ± 0.09 µmol/L (mean ± SE) and from 0.22 ± 0.07 to 0.39 ± 0.03 µmol/L, respectively, (p < 0.001 for both) after 3 months, whereas SDMA did not change. The concentrations of ADMA and L-NMMA were higher in CH (3.48 ± 0.07, 0.53 ± 0.08 µmol/L; p < 0.001) as compared with CIH. In both CIH and CH, ADMA correlated with hematocrit (r2 = 0.07, p < 0.05; r2 = 0.26; p < 0.01). In CIH, an association of ADMA levels with poor acclimatization status was observed. We conclude that the endogenous NO synthase inhibitors, ADMA and L-NMMA, are elevated in hypoxia. This may contribute to impaired NO production at altitude and may also be predictive of altitude-associated health impairment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / ômega-N-Metilarginina / Altitude / Aclimatação / Hipóxia Tipo de estudo: Etiology_studies Limite: Adolescent / Adult / Humans / Male País/Região como assunto: America do sul / Chile Idioma: En Revista: High Alt Med Biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / ômega-N-Metilarginina / Altitude / Aclimatação / Hipóxia Tipo de estudo: Etiology_studies Limite: Adolescent / Adult / Humans / Male País/Região como assunto: America do sul / Chile Idioma: En Revista: High Alt Med Biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos