[Prevalence of potential drug interactions with azithromycin in Colombia, 2012-2013]. / Prevalencia de potenciales interacciones farmacológicas de Azitromicina en Colombia, 2012-2013.
Rev Salud Publica (Bogota)
; 17(3): 463-469, 2015 May.
Article
em Es
| MEDLINE
| ID: mdl-28453094
Objective To determine the prevalence of potential drug interactions between azithromycin and different IA and III antiarrhythmic groups in a national database of drug prescriptions in 2012-2013. Methods Retrospective study based on a population database of medicine dispensation. Data from patients who received azithromycin between January 1, 2012 and June 30, 2013 were extracted along with data from patients who received azithromycin in combination with other medications shown to cause heart arrhythmias when used concomitantly. Frequencies and proportions were established. Results 13 859 patients receiving azithromycin alone or in combination with other drugs were identified. The average time of use was 4.5 ± 0.9 days. A total of 702 patients (5.1 %) received azithromycin plus 19 other potentially risky drugs. The most frequently associated were loratadine (77.1 %), diphenhydramine (16.5 %) and amitriptyline (8.1 %). Combinations with a single drug were the most frequent (n=533, 75.9 %), predominantly azithromycin+loratadine. The maximum number of combined drugs was six (n=2, 0.3 %). Conclusions Identification of drug prescriptions through population databases is an effective way to find potential drug interactions. The frequency of potential interactions between azithromycin and other drugs is common in Colombian patients. Future research should assess the risk of occurrence of adverse cardiac events.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Screening_studies
País/Região como assunto:
America do sul
/
Colombia
Idioma:
Es
Revista:
Rev Salud Publica (Bogota)
Assunto da revista:
SAUDE PUBLICA
Ano de publicação:
2015
Tipo de documento:
Article
País de publicação:
Colômbia