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Comment on Indoxyl Sulfate-Review of Toxicity and Therapeutic Strategies. Toxins 2016, 8, 358.
Barreto, Fellype C; Barreto, Daniela V; Stinghen, Andrea E M; Massy, Ziad A.
Afiliação
  • Barreto FC; Division of Nephrology, Department of Internal Medicine, Federal University of Paraná, 80060-900 Curitiba, Brazil. fellype.barreto@ufpr.br.
  • Barreto DV; Division of Nephrology, Department of Internal Medicine, Federal University of Paraná, 80060-900 Curitiba, Brazil. danielaveitbarreto@gmail.com.
  • Stinghen AEM; Experimental Nephrology Laboratory, Basic Pathology Department, Federal University of Paraná, 81531-980 Curitiba, Brazil. andreastinghen@ufpr.br.
  • Massy ZA; Division of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt, Paris 92104, France. ziad.massy@aphp.fr.
Toxins (Basel) ; 9(4)2017 04 17.
Article em En | MEDLINE | ID: mdl-28420181
Recently, the clinical and experimental evidences that support the toxic effects of indoxyl sulfate, a protein-bound uremic toxin in chronic kidney disease (CKD) patients, has been discussed. In this panorama, the authors described several in vitro and in vivo studies, suggesting that indoxyl sulfate may play a part in the pathogenesis of low turnover bone disease. However, the discussion claims the need for relevant clinical studies in CKD patients whose bone turnover biomarkers and bone histomorphometry were assessed in order to demonstrate the association between serum levels of indoxyl sulfate and bone turnover. We would like to underline the availability of this clinical data to support the concept that indoxyl sulfate may play a part in the pathogenesis of low turnover bone disease in CKD patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxinas Biológicas / Indicã Limite: Humans Idioma: En Revista: Toxins (Basel) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxinas Biológicas / Indicã Limite: Humans Idioma: En Revista: Toxins (Basel) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça