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[Risk factors for acute kidney injury in patients treated with polymyxin B experience from 139 cases at a tertiary university hospital in Colombia]. / Factores asociados a nefrotoxicidad por polimixina B en un hospital universitario de Neiva, Colombia. 2011-2015.
Osorio, Johanna; Barreto, Jackeline; Samboni, Claudia F; Cándelo, Lina A; Álvarez, Luis C; Benavidez, Susana; Téllez, Roso P; Santofimio, Dagoberto; Ramos, Jorge A; Gómez, Carlos A.
Afiliação
  • Osorio J; Grupo de Investigación Infecto Control, Neiva, Huila, Colombia.
  • Barreto J; Grupo de Investigación Infecto Control, Neiva, Huila, Colombia.
  • Samboni CF; Departamento de Epidemiología, Universidad Surcolombiana, Neiva, Huila, Colombia.
  • Cándelo LA; Departamento de Epidemiología, Universidad Surcolombiana, Neiva, Huila, Colombia.
  • Álvarez LC; Departamento de Epidemiología, Universidad Surcolombiana, Neiva, Huila, Colombia.
  • Benavidez S; Hospital Universitario, Neiva, Huila, Colombia.
  • Téllez RP; Hospital Universitario, Neiva, Huila, Colombia.
  • Santofimio D; Grupo de Investigación Infecto Control, Neiva, Huila, Colombia.
  • Ramos JA; Grupo de Investigación Infecto Control, Neiva, Huila, Colombia.
  • Gómez CA; Grupo de Investigación Infecto Control, Neiva, Huila, Colombia.
Rev Chilena Infectol ; 34(1): 7-13, 2017 Feb.
Article em Es | MEDLINE | ID: mdl-28394975
BACKGROUND: The rise of infections caused by multidrug-resistant Gram negative bacilli (MDR-GNB), added to paucity of newer therapy, have led to increase polymyxin B use, despite adverse renal toxicity profile. AIM: To determine the incidence and risk factors associated to acute kidney injury (AKI) and polymyxin B use, in patients with infections caused by MDR-GNB. METHODS: A retrospective cohort, with a nested case-control study of adults who received polymyxin B for more than 48 hours at a tertiary university hospital in Colombia (2011-2015) was performed. AKI was defined by AKIN criteria. RESULTS: Of 139 patients included in our study, 102 were male with median age of 49 years (IQR:28-64). Sixty-one patients (44%) developed AKI. Independent risk factors for development of AKI included: total polymyxin B daily dose (OR = 2.19, 95% CI, 1.04-4.64); length of stay at ICU (OR = 1.03, 95% CI, 1.00-1.06); nosocomial infection (OR = 6.43, 95% CI, 2.12, -19.47); and vasopressor use (OR = 5.38, 95% CI, 2.40-12.07). Mortality was higher among AKI-patients (58.6%) compared with non-AKI patients (25.6%) (p = 0.001). CONCLUSION: In this study, the rate of AKI associated to polymyxin B use was greater than reported in studies from last decade, and associated with increased mortality. AKI associated to polymyxin B use is likely multifactorial and aggravated by the critically ill state of patients suffering nosocomial infections caused by mdr-gnb.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimixina B / Injúria Renal Aguda / Antibacterianos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: Es Revista: Rev Chilena Infectol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Chile
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimixina B / Injúria Renal Aguda / Antibacterianos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: Es Revista: Rev Chilena Infectol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Chile