Angiotensin converting enzyme activity in the amygdaloid complex in a neurogenic hypertensive model.
Clin Exp Hypertens A
; 10(4): 605-15, 1988.
Article
em En
| MEDLINE
| ID: mdl-2839312
The bilateral destruction of the ventral noradrenergic pathway induced by 6-hydroxydopamine (6-OHDA) administration into the ventral pons led to an increase in arterial blood pressure (ABP) and norepinephrine depletion in the amygdaloid complex, nucleus accumbens, septal area and olfactory bulb. Specific angiotensin converting enzyme (ACE) activity was significantly increased only in the amygdaloid complex (Control: 4.56 +/- 0.95; Vehicle: 4.08 +/- 1.07; 6-OHDA: 11.76 +/- 1.84). A significant correlation between arterial blood pressure and specific ACE activity levels in the amygdaloid complex was observed (r: 0.775; p less than 0.002). These results suggest that an increase in specific ACE activity of the amygdaloid complex after norepinephrine depletion could play a role in the development of hypertension in this model.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptidil Dipeptidase A
/
Tonsila do Cerebelo
/
Hipertensão
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Clin Exp Hypertens A
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Estados Unidos