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Age as A Predictor of Embryo Quality Regardless of The Quantitative Ovarian Response.
Scheffer, Juliano Brum; Scheffer, Bruno Brum; de Carvalho, Rafaela Friche; Rodrigues, Joyce; Grynberg, Michael; Mendez Lozano, Daniel H.
Afiliação
  • Scheffer JB; Brazilian Institute of Assisted Reproduction, Belo Horizonte, Brazil.
  • Scheffer BB; Brazilian Institute of Assisted Reproduction, Belo Horizonte, Brazil.
  • de Carvalho RF; Brazilian Institute of Assisted Reproduction, Belo Horizonte, Brazil.
  • Rodrigues J; Brazilian Institute of Assisted Reproduction, Belo Horizonte, Brazil.
  • Grynberg M; Department of Reproductive Medicine, Hospital Jean Verdier (AP-HP), University Paris XIII, and INSERM, Paris, France.
  • Mendez Lozano DH; School of Medicine, Tecnológico de Monterrey and Center for Reproductive Medicine CREASIS San Pedro Monterrey, México.
Int J Fertil Steril ; 11(1): 40-46, 2017.
Article em En | MEDLINE | ID: mdl-28367304
BACKGROUND: One determining factor of a successful in vitro fertilization (IVF) cycle is embryo quality. The aim of the present study was to evaluate associations of embryo quality and reserve markers like age, FSH and AMH. MATERIALS AND METHODS: In this prospective study, 120 infertile women, aged 21-44 years, undergoing routine exploration during an unstimulated cycle preceding assisted reproductive technology (ART) at our center were studied prospectively, from February 2011 to December 2014. Descriptive parameters and patient characteristics were reported as mean (SD) or median (range) depending on the distribution. Student's t test was performed for continuous variables, Wilcoxon and Pearson's Test were used for not distributed variables and Fisher's Test was performed for categorical variables. P<0.05 was considered statistically significant. RESULTS: Overall, at the time of investigation, patients had a mean age of 33.03 ± 4.15 years old. On cycle day three, serum anti-Mullerian hormone (AMH) level was 3.50 ± 1.54 ng/mL, serum follicle-stimulating hormone (FSH) level was 6.29 ± 1.53 mUI/ mL, at baseline, women had 16.57 ± 7.0 antral follicles. The mean of collected oocytes was 11.80 ± 5.25, embryo I+II was 2.46 ± 2.11. A greater number of embryos I+II was observed in young patients. By evaluating 120 patients, a significant relationship was observed between age and FSH (r=0.24, P=0.01), age with AMH (r=-0.22, P=0.02), age with collected oocytes (r=-0.23, P=0.03) and age with embryo I+II (r=-0.22, P=0.03). A significant relationship was also observed between antral follicle count (AFC) and AMH (r=0.29, P=0.01), AFC and the number of transferred embryo (r=-0.18, P=0.03), AFC and total dose of the drugs (r=-0.23, P=0.03). Significant relationship of FSH with total dose of drugs (r=0.19, P=0.02) was also observed. In addition, we determined significant relationships between AMH and the number of collected oocytes (r=0.38, P=0.01), AMH and the number of metaphase II oocytes (r= 0.35, P=0.01), AMH and the number of embryo (r=0.19, P=0.04) as well as AMH and total dose of the drugs (r=-0.25, P=0.01). CONCLUSION: Commonly used clinical markers of ovarian reserve are reflection of the ovarian reserve, while the outcome measurements of ART and age are the best predictors of embryo quality.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Int J Fertil Steril Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irã

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Int J Fertil Steril Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irã