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Role of Th1/Th2 cytokines in the diagnosis and prognostic evaluation of ankylosing spondylitis.
Wen, J T; Zhang, D H; Fang, P F; Li, M H; Wang, R J; Li, S H.
Afiliação
  • Wen JT; Department of Orthopedics, TCM Hospital of Gansu Province, Lanzhou, Gansu, China.
  • Zhang DH; Department of Orthopedics, TCM Hospital of Gansu Province, Lanzhou, Gansu, China dehongzhangf@sina.com.
  • Fang PF; Department of Orthopedics, the Baiyin branch of TCM Hospital of Gansu Province, Lanzhou, Gansu, China.
  • Li MH; Department of Orthopedics, the Baiyin branch of TCM Hospital of Gansu Province, Lanzhou, Gansu, China.
  • Wang RJ; Department of Orthopedics, the Baiyin branch of TCM Hospital of Gansu Province, Lanzhou, Gansu, China.
  • Li SH; Department of Orthopedics, TCM Hospital of Gansu Province, Lanzhou, Gansu, China.
Genet Mol Res ; 16(1)2017 Mar 16.
Article em En | MEDLINE | ID: mdl-28362980
Ankylosing spondylitis (AS), a progressive disease of the spine, manifests as peripheral arthritis with tendon and ligament inflammation that restricts activity. AS is a rheumatoid autoimmune disease although the rheumatoid factor is absent in patients with AS. It is characterized by inflammatory changes such as elevated levels of serum inflammatory factors. The roles of Th1 and Th2 cytokines in autoimmune diseases are well known. However, the roles of these cytokines in the diagnosis and prognosis of AS is poorly understood. The aim of this study was to investigate the roles of Th1/Th2 cytokines in the diagnosis and prognosis of AS. The BASDAI activity, BASFI functional index, BASMI measurement score, and the levels of CRP and ESR were measured during the treatment of patients with active AS. The levels of IFN-γ and TNF-α (Th1 cytokines) and IL-4 and IL-10 (Th2 cytokines) were quantified. The levels of IL-4 and IL-10 were significantly low in the serum of patients with active AS, who also had high IFN-γ and TNF-α levels compared to those in the control individuals (P < 0.05). After treatment, the levels of IL-4 and IL-10 increased while those of IFN-γ and TNF-α decreased compared to those in individuals with active AS (P < 0.05). The disease activity index correlated positively with levels of IFN-γ and TNF-α and negatively with levels of IL-4 and IL-10, but not with that of CRP or ESR. Changes in the levels of Th1/2 cytokines in patients with AS may reflect disease activity and prognosis.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espondilite Anquilosante / Anti-Inflamatórios não Esteroides / Citocinas / Células Th2 / Células Th1 Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espondilite Anquilosante / Anti-Inflamatórios não Esteroides / Citocinas / Células Th2 / Células Th1 Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Brasil