Your browser doesn't support javascript.
loading
Pharmacogenetics in the treatment of pre-eclampsia: current findings, challenges and perspectives.
Luizon, Marcelo R; Palei, Ana Ct; Cavalli, Ricardo C; Sandrim, Valeria C.
Afiliação
  • Luizon MR; Department of Pharmacology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, Sao Paulo 18680-000, Brazil.
  • Palei AC; Department of General Biology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.
  • Cavalli RC; Department of Surgery, Division of Pediatric & Congenital Heart Surgery, University of Mississippi Medical Center, Jackson, MS 39216, USA.
  • Sandrim VC; Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Pharmacogenomics ; 18(6): 571-583, 2017 Apr.
Article em En | MEDLINE | ID: mdl-28358601
Pre-eclampsia (PE) is defined as pregnancy-induced hypertension and proteinuria, and is a major cause of maternal and perinatal morbidity and mortality. A large subgroup of pregnant women with PE is nonresponsive to antihypertensive drugs, including methyldopa, nifedipine and hydralazine. Pharmacogenomics may help to guide the individualized therapy for this nonresponsive subgroup. However, just a few pharmacogenetic studies examined the effects of genetic polymorphisms on response to antihypertensive drugs in PE, and the criteria of responsiveness used to define responsive or nonresponsive subgroups to antihypertensive therapy should be replicated by others. We review these gene-drugs interactions, novel approaches to pharmacogenomics research and potential novel drugs for PE therapy. Finally, we discuss the challenges and perspectives of pharmacogenetics in the treatment of PE.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Testes Farmacogenômicos / Variantes Farmacogenômicos / Anti-Hipertensivos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: Pharmacogenomics Assunto da revista: FARMACOLOGIA / GENETICA MEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Testes Farmacogenômicos / Variantes Farmacogenômicos / Anti-Hipertensivos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: Pharmacogenomics Assunto da revista: FARMACOLOGIA / GENETICA MEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido