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The Frequency of HLA-B27 in a Colombian Population with Signs of Spondyloarthritis.
Romero-Sanchez, Consuelo; Chila-Moreno, Lorena; Gómez, Alberto; Casas G, Maria Consuelo; Bautista-Molano, Wilson; Briceño, Ignacio; Rueda, Juan C; De Avila, Juliette; Londono, John; Valle-Onate, Rafael.
Afiliação
  • Romero-Sanchez C; Spondyloarthropaty Group, Division of Rheumatology, Hospital Militar Central, Bogota, Colombia.
  • Chila-Moreno L; UIBO Institute (Oral Basic Research Unit), Universidad El Bosque, Bogota, Colombia.
  • Gómez A; Instituto de Referencia Andino, Bogota, Colombia.
  • Casas G MC; Faculty of Medicine, Universidad Militar Nueva Granada, Bogota, Colombia.
  • Bautista-Molano W; UIBO Institute (Oral Basic Research Unit), Universidad El Bosque, Bogota, Colombia.
  • Briceño I; Instituto de Referencia Andino, Bogota, Colombia.
  • Rueda JC; Institute of Human Genetics, Faculty of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia.
  • De Avila J; Instituto de Referencia Andino, Bogota, Colombia.
  • Londono J; Faculty of Medicine, Universidad Militar Nueva Granada, Bogota, Colombia.
  • Valle-Onate R; Institute of Human Genetics, Faculty of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia.
Curr Rheumatol Rev ; 14(3): 246-250, 2018.
Article em En | MEDLINE | ID: mdl-28356051
BACKGROUND: The strong association between HLA-B27 and spondyloarthritis (SpA) has demonstrated that typing the HLA-B27 antigen is a crucial step in diagnosis and aids in defining the progression and severity of disease. OBJECTIVE: To describe the frequency of HLA-B27 in Colombian individuals with clinical manifestations associated with SpA. MATERIALS AND METHODOLOGY: We retrospectively analyzed 4109 HLA-B27 typing requests to the Hospital Militar Central and the Instituto de Referencia Andino from Colombian individuals with clinical signs suggestive of SpA between 2009 and 2012. We used basic digital cytometry followed by Polymerase Chain Reaction with sequence specific primers when confirmation was needed. We determined the frequency of HLA-B27 in the population and levels of association of HLA-B27 with SpA. RESULTS: Our population included 1585 men (36.8%) and 2524 women (61.4%). The predominant age range was between 19 and 45 years (49.9%). The majority (95.4%) of the study population came from the Andean region and eastern plains. The most frequent clinical manifestations were peripheral. Only a small fraction (12.1%) of the 4109 subjects was HLA-B27 positive. Of those, 56.9% were male, and 54.7% were between 19 and 45 years old. In contrast, when rheumatologists referred the HLA B27, 64% were found to be positive. CONCLUSION: The frequency of the HLA-B27 allele in individuals with clinical signs suggestive of SpA was low, in accordance with the lower prevalence found in Colombian patients diagnosed with SpA compared to American and European population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígeno HLA-B27 / Espondilartrite Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En Revista: Curr Rheumatol Rev Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Emirados Árabes Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígeno HLA-B27 / Espondilartrite Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En Revista: Curr Rheumatol Rev Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Emirados Árabes Unidos