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Oxidative stress and immune system analysis after cycle ergometer use in critical patients.
França, Eduardo Eriko Tenório de; Ribeiro, Luana Carneiro; Lamenha, Gabriela Gomes; Magalhães, Isabela Kalline Fidelix; Figueiredo, Thainá de Gomes; Costa, Marthley José Correia; Elihimas, Ubiracé Fernando; Feitosa, Bárbara Luana; Andrade, Maria do Amparo; Correia, Marco Aurélio Valois; Ramos, Francimar Ferrari; Castro, Célia Maria Machado Barbosa de.
Afiliação
  • França EE; Universidade Católica de Pernambuco (UNICAP), Fisioterapia, Recife/PE, Brazil.
  • Ribeiro LC; Universidade Federal de Pernambuco (UFPE), Fisioterapia, Recife/PE, Brazil.
  • Lamenha GG; Hospital Agamenom Magalhães (HAM), Fisioterapia, Recife/PE, Brazil.
  • Magalhães IK; Universidade Federal de Pernambuco (UFPE), Fisioterapia, Recife/PE, Brazil.
  • Figueiredo TG; Hospital Agamenom Magalhães (HAM), Fisioterapia, Recife/PE, Brazil.
  • Costa MJ; Hospital Agamenom Magalhães (HAM), Fisioterapia, Recife/PE, Brazil.
  • Elihimas UF; Hospital Agamenom Magalhães (HAM), Fisioterapia, Recife/PE, Brazil.
  • Feitosa BL; Hospital Agamenom Magalhães (HAM), Fisioterapia, Recife/PE, Brazil.
  • Andrade MD; Universidade Católica de Pernambuco (UNICAP), Fisioterapia, Recife/PE, Brazil.
  • Correia MA; Hospital Agamenom Magalhães (HAM), UTI Geral, Medicina Intensiva, Recife/, PE, Brazil.
  • Ramos FF; Universidade Católica de Pernambuco (UNICAP), Fisioterapia, Recife/PE, Brazil.
  • Castro CM; Universidade Federal de Pernambuco (UFPE), Fisioterapia, Recife/PE, Brazil.
Clinics (Sao Paulo) ; 72(3): 143-149, 2017 Mar.
Article em En | MEDLINE | ID: mdl-28355359
OBJECTIVE:: The passive cycle ergometer aims to prevent hypotrophy and improve muscle strength, with a consequent reduction in hospitalization time in the intensive care unit and functional improvement. However, its effects on oxidative stress and immune system parameters remain unknown. The aim of this study is to analyze the effects of a passive cycle ergometer on the immune system and oxidative stress in critical patients. METHODS:: This paper describes a randomized controlled trial in a sample of 19 patients of both genders who were on mechanical ventilation and hospitalized in the intensive care unit of the Hospital Agamenom Magalhães. The patients were divided into two groups: one group underwent cycle ergometer passive exercise for 30 cycles/min on the lower limbs for 20 minutes; the other group did not undergo any therapeutic intervention during the study and served as the control group. A total of 20 ml of blood was analysed, in which nitric oxide levels and some specific inflammatory cytokines (tumour necrosis factor alpha (TNF-α), interferon gamma (IFN-γ) and interleukins 6 (IL-6) and 10 (IL-10)) were evaluated before and after the study protocol. RESULTS:: Regarding the demographic and clinical variables, the groups were homogeneous in the early phases of the study. The nitric oxide analysis revealed a reduction in nitric oxide variation in stimulated cells (p=0.0021) and those stimulated (p=0.0076) after passive cycle ergometer use compared to the control group. No differences in the evaluated inflammatory cytokines were observed between the two groups. CONCLUSION:: We can conclude that the passive cycle ergometer promoted reduced levels of nitric oxide, showing beneficial effects on oxidative stress reduction. As assessed by inflammatory cytokines, the treatment was not associated with changes in the immune system. However, further research in a larger population is necessary for more conclusive results.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Terapia Passiva Contínua de Movimento / Estado Terminal / Estresse Oxidativo Tipo de estudo: Clinical_trials / Guideline Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Terapia Passiva Contínua de Movimento / Estado Terminal / Estresse Oxidativo Tipo de estudo: Clinical_trials / Guideline Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos