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Extinction memory is facilitated by methylphenidate and regulated by dopamine and noradrenaline receptors.
Furini, Cristiane R G; Behling, Jonny A K; Zinn, Carolina G; Zanini, Mara Lise; Assis Brasil, Eduardo; Pereira, Luiza Doro; Izquierdo, Ivan; de Carvalho Myskiw, Jociane.
Afiliação
  • Furini CRG; Memory Center, Brain Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, 6690-2nd Floor, 90610-000, Porto Alegre, RS, Brazil; National Institute of Translational Neuroscience (INNT), National Research Council of Brazil, Brazil.
  • Behling JAK; Memory Center, Brain Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, 6690-2nd Floor, 90610-000, Porto Alegre, RS, Brazil.
  • Zinn CG; Memory Center, Brain Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, 6690-2nd Floor, 90610-000, Porto Alegre, RS, Brazil.
  • Zanini ML; College of Chemistry, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, 6681, 90619-900. Porto Alegre, RS, Brazil.
  • Assis Brasil E; Memory Center, Brain Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, 6690-2nd Floor, 90610-000, Porto Alegre, RS, Brazil.
  • Pereira LD; Memory Center, Brain Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, 6690-2nd Floor, 90610-000, Porto Alegre, RS, Brazil.
  • Izquierdo I; Memory Center, Brain Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, 6690-2nd Floor, 90610-000, Porto Alegre, RS, Brazil; National Institute of Translational Neuroscience (INNT), National Research Council of Brazil, Brazil. Electronic address: izquier@terra.com.
  • de Carvalho Myskiw J; Memory Center, Brain Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, 6690-2nd Floor, 90610-000, Porto Alegre, RS, Brazil; National Institute of Translational Neuroscience (INNT), National Research Council of Brazil, Brazil. Electronic address: jociane_carvalho@h
Behav Brain Res ; 326: 303-306, 2017 05 30.
Article em En | MEDLINE | ID: mdl-28341611
Extinction is defined as the learned inhibition of retrieval and is the mainstay of exposure therapy, which is widely used to treat drug addiction, phobias and fear disorders. The psychostimulant, methylphenidate (MPH) is known to increase extracellular levels of noradrenaline and dopamine by blocking their reuptake and studies have demonstrated that MPH can modulate hippocampal physiology and/or functions including long-term potentiation (LTP), learning and memory. However, the influence of MPH on fear extinction memory has been insufficiently studied. Here we investigate the effect of MPH infused into the CA1 region of the hippocampus on extinction memory in animals normally incapable of showing contextual fear conditioning (CFC) extinction because of weak training, and the possible mechanisms through which it acts during this process. For this, male Wistar rats with infusion cannulae stereotaxically implanted in the CA1 region were submitted to a weak extinction protocol in a CFC apparatus. Animals that received intra-CA1 infusion of MPH (12.5µg/side) 20min before the extinction training (Ext Tr) expressed less freezing behavior than Veh-treated animals during both Ext Tr and extinction retention Test (Ext Test). Additionally, the administration of MPH+Timolol (1µg/side) or MPH+SCH23390 (1.5µg/side) intra-CA1 20min before the Ext Tr blocked the enhancing effect of the MPH on extinction learning. These results suggest that MPH in the CA1 region of the hippocampus is able to induce the consolidation of extinction memory and this process occurs through both ß-adrenergic and D1/D5 dopaminergic receptors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Receptores Adrenérgicos beta / Receptores Dopaminérgicos / Antagonistas Adrenérgicos beta / Antagonistas de Dopamina / Extinção Psicológica / Região CA1 Hipocampal / Consolidação da Memória / Estimulantes do Sistema Nervoso Central / Metilfenidato Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Behav Brain Res Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Receptores Adrenérgicos beta / Receptores Dopaminérgicos / Antagonistas Adrenérgicos beta / Antagonistas de Dopamina / Extinção Psicológica / Região CA1 Hipocampal / Consolidação da Memória / Estimulantes do Sistema Nervoso Central / Metilfenidato Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Behav Brain Res Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda