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Combined training, FNDC5/irisin levels and metabolic markers in obese men: A randomised controlled trial.
Bonfante, Ivan Luiz Padilha; Chacon-Mikahil, Mara Patrícia Traina; Brunelli, Diego Trevisan; Gáspari, Arthur Fernandes; Duft, Renata Garbellini; Lopes, Wendell Arhur; Bonganha, Valéria; Libardi, Cleiton Augusto; Cavaglieri, Cláudia Regina.
Afiliação
  • Bonfante IL; a Laboratory of Exercise Physiology, Faculty of Physical Education , University of Campinas , Campinas , São Paulo , Brazil.
  • Chacon-Mikahil MP; a Laboratory of Exercise Physiology, Faculty of Physical Education , University of Campinas , Campinas , São Paulo , Brazil.
  • Brunelli DT; a Laboratory of Exercise Physiology, Faculty of Physical Education , University of Campinas , Campinas , São Paulo , Brazil.
  • Gáspari AF; a Laboratory of Exercise Physiology, Faculty of Physical Education , University of Campinas , Campinas , São Paulo , Brazil.
  • Duft RG; a Laboratory of Exercise Physiology, Faculty of Physical Education , University of Campinas , Campinas , São Paulo , Brazil.
  • Lopes WA; a Laboratory of Exercise Physiology, Faculty of Physical Education , University of Campinas , Campinas , São Paulo , Brazil.
  • Bonganha V; a Laboratory of Exercise Physiology, Faculty of Physical Education , University of Campinas , Campinas , São Paulo , Brazil.
  • Libardi CA; b Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education , Federal University of São Carlos , São Carlos , São Paulo , Brazil.
  • Cavaglieri CR; a Laboratory of Exercise Physiology, Faculty of Physical Education , University of Campinas , Campinas , São Paulo , Brazil.
Eur J Sport Sci ; 17(5): 629-637, 2017 Jun.
Article em En | MEDLINE | ID: mdl-28287024
The effects of training on FNDC5/irisin and its association with fitness and metabolic marker improvements induced by training have been poorly investigated in humans. Thus, the present study assessed the effects of combined training (CT) on FNDC5/irisin levels, metabolic markers and fitness adaptations in obese men. Middle-age obese men (age 49.13 ± 5.75, body mass index (BMI) 30.86 ± 1.63) were randomly distributed in the CT group (n = 12) and control group (CG n = 10). The CT consisted of strength followed by aerobic training, 3 times/week, for 24 weeks. Body composition, physical fitness, plasma FNDC5/irisin, biochemical markers and metabolic scores/index were evaluated. CT maintained FNDC5/irisin levels (µg/mL) (pre: 4.15 ± 0.32, post: 4.21 ± 0.32; p = .96) and improved body composition, metabolic and physical fitness markers. In the CG, decreased FNDC5/irisin (µg/mL) (pre: 4.36 ± 0.23, post: 3.57 ± 0.94; p = .01) and reduced strength (supine exercise/kg) (pre: 71 ± 14.7, post: 60.1 ± 14.05; p < .01) were observed, along with a trend to increase HOMA-IR (pre: 2.63 ± 1.11, post: 3.14 ± 1.27; p = .07) and other indicators of metabolic deterioration. An inverse correlation was found between the change (Δ%) in levels of FNDC5/irisin and Δ% glucose, Δ% total cholesterol, Δ% triglycerides and Δ% waist circumference, in addition to a positive relation with Δ% muscle strength. In conclusion, CT maintained FNDC5/irisin levels and provided metabolic and fitness benefits. The correlation between FNDC5/irisin changes and metabolic parameters, as well as the FNDC5/irisin reduction associated with fitness and metabolic worsening in the CG, suggests a relationship between FNDC5/irisin and a healthy metabolic status in humans.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Exercício Físico / Fibronectinas / Força Muscular / Circunferência da Cintura / Lipídeos / Obesidade Tipo de estudo: Clinical_trials Limite: Adult / Humans / Male / Middle aged Idioma: En Revista: Eur J Sport Sci Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Exercício Físico / Fibronectinas / Força Muscular / Circunferência da Cintura / Lipídeos / Obesidade Tipo de estudo: Clinical_trials Limite: Adult / Humans / Male / Middle aged Idioma: En Revista: Eur J Sport Sci Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido