Revisiting Previously Investigated Plants: A Molecular Networking-Based Study of Geissospermum laeve.
J Nat Prod
; 80(4): 1007-1014, 2017 04 28.
Article
em En
| MEDLINE
| ID: mdl-28282127
Three new monoterpene indole alkaloids (1-3) have been isolated from the bark of Geissospermum laeve, together with the known alkaloids (-)-leuconolam (4), geissolosimine (5), and geissospermine (6). The structures of 1-3 were elucidated by analysis of their HRMS and NMR spectroscopic data. The absolute configuration of geissolaevine (1) was deduced from the comparison of experimental and theoretically calculated ECD spectra. The isolation workflow was guided by a molecular networking-based dereplication strategy using an in-house database of monoterpene indole alkaloids. In addition, five known compounds previously undescribed in the Geissospermum genus were dereplicated from the G. laeve alkaloid extract network and were assigned with various levels of identification confidence. The antiparasitic activities against Plasmodium falciparum and Leishmania donovani as well as the cytotoxic activity against the MRC-5 cell line were determined for compounds 1-5.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Folhas de Planta
/
Apocynaceae
/
Alcaloides de Triptamina e Secologanina
/
Antimaláricos
/
Antiparasitários
Limite:
Humans
País/Região como assunto:
America do sul
/
Guyana francesa
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
França
País de publicação:
Estados Unidos