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Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats.
Dani, Caroline; Andreazza, Ana Cristina; Gonçalves, Carlos Alberto; Kapizinski, Flávio; Henriques, João A P; Salvador, Mirian.
Afiliação
  • Dani C; Instituto de Biotecnologia, Universidade de Caxias do Sul/UCS, Rua Francisco Getúlio Vargas, 1130, 95070-560 Caxias do Sul, RS, Brazil.
  • Andreazza AC; Centro Universitário Metodista IPA, Rua Joaquim Pedro Salgado, 80, Rio Branco, 90420-060 Porto Alegre, RS, Brazil.
  • Gonçalves CA; Department of Psychiatry, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8 Canada.
  • Kapizinski F; Universidade Federal do Rio Grande do Sul/UFRGS, Avenida Ramiro Barcelos, 2350, 90035-903 Porto Alegre, RS, Brazil.
  • Henriques JAP; Universidade Federal do Rio Grande do Sul/UFRGS, Avenida Ramiro Barcelos, 2350, 90035-903 Porto Alegre, RS, Brazil.
  • Salvador M; Instituto de Biotecnologia, Universidade de Caxias do Sul/UCS, Rua Francisco Getúlio Vargas, 1130, 95070-560 Caxias do Sul, RS, Brazil.
An Acad Bras Cienc ; 89(1): 155-161, 2017.
Article em En | MEDLINE | ID: mdl-28273245
Several studies have shown that a high consumption of vegetables and fruits is consistently associated with a low risk of oxidative stress-induced diseases, which includes some degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer and Parkinson. Therefore, the objective of this study is to verify the effects of conventional and organic grape juice in the modulation of the neurotrophic factor (BDNF) and astrocytic markers protein (S100B) in hippocampus and frontal cortex of Wistar rats. In this study, 24 male Wistar rats were divided into three groups. To the first one, it was given organic purple grape juice; to the second, conventional grape juice, while the last one received only saline. After 30 days, all rats were sacrificed and hippocampus and frontal cortex were dissected. The animals that received organic and conventional grape juice showed, in frontal cortex, an elevated BNDF levels in relation to saline group. However, S100B levels did not change. These results showed that grape juices are able to modulate important marker in brain tissue, and could be an important factor to prevent brain diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Vitis / Subunidade beta da Proteína Ligante de Cálcio S100 / Sucos de Frutas e Vegetais / Lobo Frontal / Hipocampo Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Revista: An Acad Bras Cienc Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Vitis / Subunidade beta da Proteína Ligante de Cálcio S100 / Sucos de Frutas e Vegetais / Lobo Frontal / Hipocampo Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Revista: An Acad Bras Cienc Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil