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Prevalence of Helicobacter pylori Infection in Samples of Gastric Biopsies.
Trindade, Leda Maria Delmondes Freitas; Menezes, Lania Barreto de Oliveira; de Souza Neta, Adozina Marques; Leite Rolemberg, Paulo Candido; Souza, Lais Dantas; Barreto, Ikaro Daniel de Carvalho; Meurer, Luise.
Afiliação
  • Trindade LM; Department of Medicine, Tiradentes University, Aracaju 49032-490, Brazil.
  • Menezes LB; Department of Medicine, Tiradentes University, Aracaju 49032-490, Brazil.
  • de Souza Neta AM; Department of Medicine, Tiradentes University, Aracaju 49032-490, Brazil.
  • Leite Rolemberg PC; Department of Medicine, Tiradentes University, Aracaju 49032-490, Brazil.
  • Souza LD; Department of Medicine, Tiradentes University, Aracaju 49032-490, Brazil.
  • Barreto ID; Biometrics and Applied Statistics - PPGBEA - UFRPE, Aracaju 49160-000, Brazil.
  • Meurer L; Department of Gastroenterology and Hepatology, Laboratory of Pathological Anatomy Dra. Monica Araujo (LAPMA), Aracaju 49015-230, Brazil.
Gastroenterology Res ; 10(1): 33-41, 2017 Feb.
Article em En | MEDLINE | ID: mdl-28270875
BACKGROUND: Helicobacter pylori (H. pylori) infection affects about 50% of the world population and its association with environmental factors and host properties is involved in gastric carcinogenesis. The study aimed to estimate the prevalence of H. pylori in samples of gastric mucosa biopsies, correlate the presence of the bacteria in the sample with the variables age, sex and origin, to identify the types of lesions found in patients with H. pylori, and to evaluate the association of the lesions with the region of the gastric mucosa. METHODS: A cross-sectional, retrospective study was carried out in Aracaju, Sergipe, Brazil, from January 2013 to December 2015. A total of 45,206 gastric mucosal biopsies were obtained from patients submitted to upper gastrointestinal endoscopy. Of the reports evaluated, 12,909 met the inclusion criteria since they presented the patient's demographic data as well as the histopathological characteristics of gastric mucosal regions and positivity for H. pylori. Data were analyzed by IBM SPSS Statistic 20 and subjected to descriptive analyses (categorical variables) and inferential (Pearson's Qui-square and linear association tests) and multiple correspondence analyses. Significance level adopted 5%. RESULTS: Of the total of 12,909 (28.6%) reports evaluated, 67% (8,647) came from urban areas and 64.5% (8,320) were female. The mean age (standard deviation (SD)) was 43 years, ranging from 8 to 100 years, prevailing between 21 and 60 years. Among the types of gastric mucosa analyzed, 95.5% (12,322) were of the antral mucosa. The absence of glandular atrophy, the mild infection intensity for H. pylori, the absence of metaplasia, the presence of foveolar hyperplasia and lymphoid follicles were statistically significant (P < 0.001) in this region. In the fundic region, the evidence of fibrinoleucocytic crust and lymphoid follicles was significant (P < 0.001). There was no evidence of associated ulcerated lesions or significant relationship with intestinal metaplasia in the antral mucosa, whereas the fundic mucosa had a strong association with lymphoid follicles. The prevalence of active H. pylori infection in this study was 30.93%. CONCLUSION: Detection rate of H. pylori and its association with acute and chronic inflammation should be taken into account. The antral region has shown higher incidence and the presence of H. pylori was strongly associated with foveolar hyperplasia and lymphoid follicles.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Gastroenterology Res Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Gastroenterology Res Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá