Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery.
Carbohydr Polym
; 163: 1-9, 2017 May 01.
Article
em En
| MEDLINE
| ID: mdl-28267484
In the present work, we study the role of different components in the formation of more stable iron oxide magnetic nanoparticles (MNPs): ß-cyclodextrin (BCD), 2-hydroxypropyl-ß-cyclodextrin (HP) and citrate anion. MNPs formulations were characterized by FTIR, particles size measurements, zeta potential based on dynamic light scattering principle technique, X-ray powder pattern diffraction, XPS spectroscopy, transmission electron microscopy and thermogravimetric analysis. The results showed that cyclodextrins and citrate plays a key role in order to obtain a lower size of coated MNPs and proved to be an efficient strategy to obtain a more stable colloidal dispersion, avoiding the nanoparticles oxidation, enhancing the irinotecan incorporation and release. Furthermore, citrate-coated BCD-MNPs showed the same cytotoxicity of the free IRI.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Carbohydr Polym
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido