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Coronary Artery Bypass Graft Surgery and Dementia Risk in the Cardiovascular Health Study.
Kuzma, Elzbieta; Airdrie, Jac; Littlejohns, Thomas J; Lourida, Ilianna; Thompson-Coon, Jo; Lang, Iain A; Scrobotovici, Monica; Thacker, Evan L; Fitzpatrick, Annette; Kuller, Lewis H; Lopez, Oscar L; Longstreth, William T; Ukoumunne, Obioha C; Llewellyn, David J.
Afiliação
  • Kuzma E; *Institute of Health Research, University of Exeter Medical School, Exeter †School of Psychology, Cardiff University, Cardiff ‡Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK §Department of Health Science, Brigham Young University, Provo, UT Departments of ∥Epidemiology **Neurology, University of Washington, Seattle, WA Departments of ¶Epidemiology #Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, PA.
Alzheimer Dis Assoc Disord ; 31(2): 120-127, 2017.
Article em En | MEDLINE | ID: mdl-28263191
INTRODUCTION: The association between history of coronary artery bypass graft surgery (CABG) and dementia risk remains unclear. METHODS: We conducted a prospective cohort analysis using data on 3155 elderly adults free from prevalent dementia from the US population-based Cardiovascular Health Study (CHS) with adjudicated incident all-cause dementia, Alzheimer disease (AD), vascular dementia (VaD), and mixed dementia. RESULTS: In the CHS, the hazard ratio (HR) for all-cause dementia was 1.93 [95% confidence interval (CI), 1.36-2.74] for those with CABG history compared with those with no CABG history after adjustment for potential confounders. Similar HRs were observed for AD (HR=1.71; 95% CI, 0.98-2.98), VaD (HR=1.42; 95% CI, 0.56-3.65), and mixed dementia (HR=2.73; 95% CI, 1.55-4.80). The same pattern of results was observed when these CHS findings were pooled with a prior prospective study, the pooled HRs were 1.96 (95% CI, 1.42-2.69) for all-cause dementia, 1.71 (95% CI, 1.04-2.79) for AD and 2.20 (95% CI, 0.78-6.19) for VaD. DISCUSSION: Our results suggest CABG history is associated with long-term dementia risk. Further investigation is warranted to examine the causal mechanisms which may explain this relationship or whether the association reflects differences in coronary artery disease severity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ponte de Artéria Coronária / Demência Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: Alzheimer Dis Assoc Disord Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ponte de Artéria Coronária / Demência Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: Alzheimer Dis Assoc Disord Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos