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Prevalence, serotyping and antimicrobials resistance mechanism of Salmonella enterica isolated from clinical and environmental samples in Saudi Arabia.
El-Tayeb, Mohamed A; Ibrahim, Abdelnasser S S; Al-Salamah, Ali A; Almaary, Khalid S; Elbadawi, Yahya B.
Afiliação
  • El-Tayeb MA; King Saud University, College of Science, Department of Botany and Microbiology, Riyadh, Saudi Arabia.
  • Ibrahim ASS; King Saud University, College of Science, Department of Botany and Microbiology, Riyadh, Saudi Arabia; National Research Center, Pharmaceutical Industries Research Division, Department of Chemistry of Natural and Microbial Products, Cairo, Egypt. Electronic address: ashebl@ksu.edu.sa.
  • Al-Salamah AA; King Saud University, College of Science, Department of Botany and Microbiology, Riyadh, Saudi Arabia.
  • Almaary KS; King Saud University, College of Science, Department of Botany and Microbiology, Riyadh, Saudi Arabia.
  • Elbadawi YB; King Saud University, College of Science, Department of Botany and Microbiology, Riyadh, Saudi Arabia.
Braz J Microbiol ; 48(3): 499-508, 2017.
Article em En | MEDLINE | ID: mdl-28245965
Salmonella is recognized as a common foodborne pathogen, causing major health problems in Saudi Arabia. Herein, we report epidemiology, antimicrobial susceptibility and the genetic basis of resistance among S. enterica strains isolated in Saudi Arabia. Isolation of Salmonella spp. from clinical and environmental samples resulted in isolation of 33 strains identified as S. enterica based on their biochemical characteristics and 16S-rDNA sequences. S. enterica serovar Enteritidis showed highest prevalence (39.4%), followed by S. Paratyphi (21.2%), S. Typhimurium (15.2%), S. Typhi and S. Arizona (12.1%), respectively. Most isolates were resistant to 1st and 2nd generation cephalosporin; and aminoglycosides. Moreover, several S. enterica isolates exhibited resistance to the first-line antibiotics used for Salmonellosis treatment including ampicillin, trimethoprim-sulfamethoxazole and chloramphenicol. In addition, the results revealed the emergence of two S. enterica isolates showing resistance to third-generation cephalosporin. Analysis of resistance determinants in S. enterica strains (n=33) revealed that the resistance to ß-lactam antibiotics, trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline, was attributed to the presence of carb-like, dfrA1, floR, tetA gene, respectively. On the other hand, fluoroquinolone resistance was related to the presence of mutations in gyrA and parC genes. These findings improve the information about foodborne Salmonella in Saudi Arabia, alarming the emergence of multi-drug resistant S. enterica strains, and provide useful data about the resistance mechanisms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Salmonella / Salmonella enterica / Farmacorresistência Bacteriana Múltipla / Antibacterianos Tipo de estudo: Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Braz J Microbiol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Arábia Saudita País de publicação: Brasil
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Salmonella / Salmonella enterica / Farmacorresistência Bacteriana Múltipla / Antibacterianos Tipo de estudo: Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Braz J Microbiol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Arábia Saudita País de publicação: Brasil