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First cases of Zika virus-infected US blood donors outside states with areas of active transmission.
Williamson, Phillip C; Linnen, Jeffrey M; Kessler, Debra A; Shaz, Beth H; Kamel, Hany; Vassallo, Ralph R; Winkelman, Valerie; Gao, Kui; Ziermann, Rainer; Menezes, Juscilene; Thomas, Stephen; Holmberg, Jerry A; Bakkour, Sonia; Stone, Mars; Lu, Kai; Simmons, Graham; Busch, Michael P.
Afiliação
  • Williamson PC; Creative Testing Solutions, Tempe, Arizona.
  • Linnen JM; Hologic, Inc, San Diego, California.
  • Kessler DA; New York Blood Center, New York, New York.
  • Shaz BH; New York Blood Center, New York, New York.
  • Kamel H; Blood Systems, Inc, Scottsdale, Arizona.
  • Vassallo RR; Blood Systems, Inc, Scottsdale, Arizona.
  • Winkelman V; Creative Testing Solutions, Tempe, Arizona.
  • Gao K; Hologic, Inc, San Diego, California.
  • Ziermann R; Hologic, Inc, San Diego, California.
  • Menezes J; Hologic, Inc, San Diego, California.
  • Thomas S; Hologic, Inc, San Diego, California.
  • Holmberg JA; Grifols Diagnostic Solutions, Inc, Emeryville, California.
  • Bakkour S; Blood Systems Research Institute, San Francisco, California.
  • Stone M; Blood Systems Research Institute, San Francisco, California.
  • Lu K; Blood Systems Research Institute, San Francisco, California.
  • Simmons G; Blood Systems Research Institute, San Francisco, California.
  • Busch MP; Blood Systems Research Institute, San Francisco, California.
Transfusion ; 57(3pt2): 770-778, 2017 03.
Article em En | MEDLINE | ID: mdl-28229475
BACKGROUND: Zika virus (ZIKV) is transmitted by Aedes mosquitos and can result in severe congenital and adult neurologic abnormalities. ZIKV has rapidly spread northward through Central America and the Caribbean and autochthonous cases have been identified in the continental United States. High rates of ZIKA RNA positivity were detected in blood donors during previous epidemics. ZIKV transmission by transfused blood from healthy donor components has been a growing concern. STUDY DESIGN AND METHODS: Individual-donation aliquots of plasma from volunteer blood donors were tested individually with an investigational Procleix ZIKV assay. Initially reactive samples were tested for ZIKV RNA in plasma and red blood cells (RBCs) and for ZIKV-specific antibodies in serum. A confirmed positive classification required confirmation of RNA and/or detection of ZIKV antibodies in index and/or follow-up samples. RESULTS: Between September 19 and November 30, 2016, a total of 466,834 donations were screened for ZIKV RNA. Five donors (one in approx. 93,000) were reactive for ZIKV RNA by both the Procleix ZIKV assay and supplemental testing. The donations were collected outside areas considered as having active transmission, and all five donors had travel exposures. A lookback case demonstrated no infection despite transfusion of a Zika IgG-positive platelet (PLT) component with probable low levels of ZIKV RNA. CONCLUSIONS: This report describes the first ZIKV-positive donors detected outside areas with active transmission. These donors most likely represent travel-acquired "tail-end infections" with prolonged RBC-associated ZIKV RNA. The lack of transmission to the recipient of an apheresis PLT may suggest that these units are not infectious.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doadores de Sangue / RNA Viral / Zika virus / Infecção por Zika virus Limite: Adult / Female / Humans / Male País/Região como assunto: America central Idioma: En Revista: Transfusion Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doadores de Sangue / RNA Viral / Zika virus / Infecção por Zika virus Limite: Adult / Female / Humans / Male País/Região como assunto: America central Idioma: En Revista: Transfusion Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos