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Efficacy and safety of a single radiofrequency ablation of solid benign non-functioning thyroid nodules.
Cesareo, Roberto; Palermo, Andrea; Pasqualini, Valerio; Simeoni, Carla; Casini, Alessandro; Pelle, Giuseppe; Manfrini, Silvia; Campagna, Giuseppe; Cianni, Roberto.
Afiliação
  • Cesareo R; Department of Internal Medicine "S. M. Goretti" Hospital, Latina, Italy.
  • Palermo A; Department of Endocrinology, University Campus Bio-Medico, Rome, Italy.
  • Pasqualini V; Department of Radiology, "S. M. Goretti" Hospital, Latina, Italy.
  • Simeoni C; Compensatory authority (INAIL), Monte Porzio Catone, Rome, Italy.
  • Casini A; Department of Internal Medicine "S. M. Goretti" Hospital, Latina, Italy.
  • Pelle G; Department of Radiology, "S. M. Goretti" Hospital, Latina, Italy.
  • Manfrini S; Department of Endocrinology, University Campus Bio-Medico, Rome, Italy.
  • Campagna G; Department of Internal Medicine "S. M. Goretti" Hospital, Latina, Italy.
  • Cianni R; Department of Radiology, "S. M. Goretti" Hospital, Latina, Italy.
Arch Endocrinol Metab ; 61(2): 173-179, 2017.
Article em En | MEDLINE | ID: mdl-28226000
OBJECTIVE: The objective of our study is to evaluate the clinical outcomes and safety of radiofrequency thermal ablation (RFA) for benign thyroid nodules (BTNs) over a 1-year follow-up. SUBJECTS AND METHODS: This is a monocentric retrospective study. Forty-eight patients with solid, non-functioning BTNs were treated by RFA using a 17G internally cooled electrode. We categorized thyroid nodules as small (≤ 12 mL), medium (12 to 30 mL), or large (over 30 mL). BTNs volume reduction, thyroid function, cosmetic and compressive score changes and side effect evaluation at 6 and 12 months were evaluated. RESULTS: BTN volume decreased significantly from baseline to 6 (mean percentage decrease of BTN volume was 66.8 ± 13.6%, p < 0.001). At 12 months, the mean percentage reduction of BTN volume compared to six months was 13.7 ± 17.1% (p < 0.001). At 6-month, symptom score had improved significantly (p < 0.001) while it does not change significantly between 6 and 12 months. In particular, symptom score improved significantly in the medium (p < 0.001) and large (p < 0.01) subgroups. Cosmetic score improved significantly between baseline and 6 months (p < 0.001) and between 6 and 12 months (p < 0.01). In all the subgroups, cosmetic score improved significantly between baseline and 6 months, while between 6 and 12 months it improved significantly only in the large group (p < 0.05). RFA was well tolerated. Only one patient experienced permanent right paramedian vocal cord palsy. CONCLUSIONS: A single RFA treatment was effective in reducing BTNs volume, in particular small and medium nodules. Cosmetic score improved in all treated BTNs while symptom score only got better in the medium and large BTNs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nódulo da Glândula Tireoide / Ablação por Cateter Tipo de estudo: Observational_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Itália País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nódulo da Glândula Tireoide / Ablação por Cateter Tipo de estudo: Observational_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Itália País de publicação: Brasil