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Visceral adiposity index and triglyceride/high-density lipoprotein cholesterol ratio in hypogonadism.
Haymana, Cem; Sonmez, Alper; Aydogdu, Aydogan; Tapan, Serkan; Basaran, Yalcin; Meric, Coskun; Baskoy, Kamil; Dinc, Mustafa; Yazici, Mahmut; Taslipinar, Abdullah; Barcin, Cem; Yilmaz, Mahmut Ilker; Bolu, Erol; Azal, Omer.
Afiliação
  • Haymana C; Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara, Turkey.
  • Sonmez A; Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara, Turkey.
  • Aydogdu A; Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara, Turkey.
  • Tapan S; Department of Biochemistry, Gulhane School of Medicine, Ankara, Turkey.
  • Basaran Y; Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara, Turkey.
  • Meric C; Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara, Turkey.
  • Baskoy K; Department of Endocrinology and Metabolism, Gulhane School of Medicine, Haydarpasa Training Hospital, Istanbul, Turkey.
  • Dinc M; Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara, Turkey.
  • Yazici M; Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara, Turkey.
  • Taslipinar A; Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara, Turkey.
  • Barcin C; Department of Cardiology, Gulhane School of Medicine, Ankara, Turkey.
  • Yilmaz MI; Department of Nephrology, Gulhane School of Medicine, Ankara, Turkey.
  • Bolu E; Department of Endocrinology and Metabolism, Memorial Atasehir Hospital, Istanbul, Turkey.
  • Azal O; Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara, Turkey.
Arch Endocrinol Metab ; 61(3): 282-287, 2017.
Article em En | MEDLINE | ID: mdl-28225990
BACKGROUND: Cardiometabolic risk is high in patients with hypogonadism. Visceral adiposity index (VAI) and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio are the practical markers of atherosclerosis and insulin resistance and independent predictors of cardiaovascular risk. To date, no study has evaluated VAI levels and TG/HDL-C ratio in hypogonadism. SUBJECTS AND METHODS: A total of 112 patients with congenital hypogonadotrophic hypogonadism (CHH) (mean age, 21.7 ± 2.06 years) and 124 healthy subjects (mean age, 21.5 ± 1.27 years) were enrolled. The demographic parameters, VAI, TG/HDL-C ratio, asymmetric dimethylarginine (ADMA), high-sensitivity C-reactive protein (hs-CRP), and homeostatic model assessment of insulin resistance (HOMA-IR) levels were measured for all participants. RESULTS: The patients had higher total cholesterol (p = 0.04), waist circumference, triglycerides, insulin, and HOMA-IR levels (p = 0.001 for all) than the healthy subjects. VAI and ADMA and TG/HDL-C levels were also higher in patients than in healthy subjects (p < 0.001 for all). VAI was weakly correlated with ADMA (r = 0.27, p = 0.015), HOMA-IR (r = 0.22, p = 0.006), hs-CRP (r = 0.19, p = 0.04), and total testosterone (r = -0.21, p = 0.009) levels, whereas TG/HDL-C ratio was weakly correlated weakly with ADMA (r = 0.30, p = 0.003), HOMA-IR (r = 0.22, p = 0.006), and total testosterone (r = -0.16, p = 0.03) levels. Neither VAI nor TG/HDL-C ratio determined ADMA, HOMA-IR, and hs-CRP levels. CONCLUSIONS: The results of this study demonstrate that patients with hypogonadism have elevated VAI and TG/HDL-C ratio. These values are significantly correlated with the surrogate markers of endothelial dysfunction, inflammation, and insulin resistance. However, the predictive roles of VAI and TG/HDL-C ratio are not significant. Prospective follow-up studies are warranted to clarify the role of VAI and TG/HDL-C ratio in predicting cardiometabolic risk in patients with hypogonadism.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Gordura Intra-Abdominal / Adiposidade / Hipogonadismo / Lipoproteínas HDL Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Gordura Intra-Abdominal / Adiposidade / Hipogonadismo / Lipoproteínas HDL Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil