Your browser doesn't support javascript.
loading
Association between C1q gene polymorphisms and autoimmune thyroid diseases.
Yao, Qiuming; Li, Jie; An, Xiaofei; Jiang, Wenjuan; Qin, Qiu; Song, Ronghua; Yan, Ni; Li, Danfeng; Jiang, Yanfei; Wang, Wen; Shi, Liangfeng; Zhang, Jin-An.
Afiliação
  • Yao Q; Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
  • Li J; Department of Nephrology, Xi'an Central Hospital, Xi'an, China.
  • An X; Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
  • Jiang W; Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
  • Qin Q; Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
  • Song R; Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
  • Yan N; Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
  • Li D; Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
  • Jiang Y; Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
  • Wang W; Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
  • Shi L; Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
  • Zhang JA; Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
Arch Endocrinol Metab ; 61(4): 337-342, 2017.
Article em En | MEDLINE | ID: mdl-28225862
OBJECTIVE: In the present study, we aimed to assess the associations of C1q gene polymorphisms with autoimmune thyroid diseases (AITD) susceptibility. SUBJECTS AND METHODS: A set of 1,003 AITD patients (661 with Graves' disease and 342 with Hashimoto's thyroiditis) and 880 ethnically- and geographically-matched controls from Chinese Han population were included. Five common single nucleotide polymorphisms (SNPs) (rs294185, rs292001, rs682658, rs665691 and rs294179) in C1q gene locus were genotyped. Frequencies of genotypes and alleles were compared between patients and controls, and haplotype analysis was also performed. RESULTS: There was no statistically significant difference between AITD patients and controls in the frequencies of alleles of rs294185 (P = 0.41), rs292001 (P = 0.71), rs682658 (P = 0.68), rs665691 (P = 0.68) and rs294179 (P = 0.69). There was also no statistically significant difference between AITD patients and controls in the frequencies of genotypes of rs294185 (P = 0.72), rs292001 (P = 0.89), rs682658 (P = 0.83), rs665691 (P = 0.90) and rs294179 (P = 0.43). Stratified analyses showed that none of those five SNPs in C1q gene were associated with Graves' disease or Hashimoto's thyroiditis (all P values > 0.05). Haplotype analysis revealed that there were no obvious genetic associations of C1q gene polymorphisms with AITD susceptibility. CONCLUSIONS: We, for the first time, identified the associations between C1q gene SNPs and AITD, and our findings suggested that five common SNPs in C1q gene were not associated with AITD susceptibility in Chinese Han population.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complemento C1q / Doença de Graves / Polimorfismo de Nucleotídeo Único / Doença de Hashimoto / Estudos de Associação Genética Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complemento C1q / Doença de Graves / Polimorfismo de Nucleotídeo Único / Doença de Hashimoto / Estudos de Associação Genética Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Brasil