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The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes.
Nunes, Rafael Almeida; Mazzotti, Diego Robles; Hirotsu, Camila; Andersen, Monica L; Tufik, Sergio; Bittencourt, Lia.
Afiliação
  • Nunes RA; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Mazzotti DR; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil. Electronic address: mazzottidr@gmail.com.
  • Hirotsu C; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Andersen ML; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Tufik S; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Bittencourt L; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Sleep Med ; 30: 210-215, 2017 02.
Article em En | MEDLINE | ID: mdl-28215251
OBJECTIVE: To verify the association between c.1083T>C polymorphism in the adenosine receptor A2A gene (ADORA2A) and objective sleep, as well as the correlation between caffeine consumption, sleep parameters, and electroencephalographic spectral power in a large, population-based sample from São Paulo, Brazil. METHODS: This study was conducted in participants of the São Paulo Epidemiologic Sleep Study (EPISONO), a large, population-based survey consisting of a representative sample of the inhabitants of the city from São Paulo, Brazil, according to sex, age (20-80 years), and socioeconomic status in the year 2007. Questionnaires, polysomnography, spectral analysis of sleep electroencephalogram, and c.1083T>C polymorphism genotyping were performed in this study. RESULTS: We found that caffeine consumption was positively correlated with sleep latency and α spectral power, as well as negatively correlated with percentage of N3 stage and δ spectral power in this stage. However, this association was identified only in T allele carriers and not in CC genotype. CONCLUSION: Our data support an important aspect of this polymorphism in ADORA2A gene, showing that the variant affects the association between caffeine consumption and objective sleep parameters in a large population-based cohort. CLINICAL TRIAL INFORMATION: Name: Epidemiology of sleep disturbances among adult population of the Sao Paulo City. URL: http://www.clinicaltrials.gov/ct2/show/NCT00596713?term = NCT00596713&rank = 1. Number: NCT00596713.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Cafeína / Receptor A2A de Adenosina / Estimulantes do Sistema Nervoso Central Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sleep Med Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Cafeína / Receptor A2A de Adenosina / Estimulantes do Sistema Nervoso Central Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sleep Med Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda