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Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells. An Intercellular Exchange of Components between Neighboring Cells.
Sanchez, Viviana; Villalba, Nerina; Fiore, Luciano; Luzzani, Carlos; Miriuka, Santiago; Boveris, Alberto; Gelpi, Ricardo J; Brusco, Alicia; Poderoso, Juan José.
Afiliação
  • Sanchez V; IBCN (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121, Buenos Aires, Argentina.
  • Villalba N; INIGEM (UBA-CONICET), Hospital de Clínicas, Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Fiore L; IBCN (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121, Buenos Aires, Argentina.
  • Luzzani C; LIAN (FLENI-CONICET), Belen de Escobar, Argentina.
  • Miriuka S; LIAN (FLENI-CONICET), Belen de Escobar, Argentina.
  • Boveris A; Cátedra de Citología, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina.
  • Gelpi RJ; Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Brusco A; IBIMOL (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Poderoso JJ; IBCN (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121, Buenos Aires, Argentina. hbrusco@fmed.uba.ar.
Stem Cell Rev Rep ; 13(4): 491-498, 2017 Aug.
Article em En | MEDLINE | ID: mdl-28214945
Intercellular communication is one of the most important events in cell population behavior. In the last decade, tunneling nanotubes (TNTs) have been recognized as a new form of long distance intercellular connection. TNT function is to allow molecular and subcellular structure exchange between neighboring cells via the transfer of molecules and organelles such as calcium ions, prions, viral and bacterial pathogens, small lysosomes and mitochondria. New findings support the concept that mesenchymal stem cells (MSCs) can affect cell microenvironment by the release of soluble factors or the transfer of cellular components to neighboring cells, in a way which significantly contributes to cell regulation and tissue repair, although the underlying mechanisms remain poorly understood. MSCs have many advantages for their implementation in regenerative medicine. The TNTs in these cell types are heterogeneous in both structure and function, probably due to their highly dynamic behavior. In this work we report an extensive and detailed description of types, structure, components, dynamics and functionality of the TNTs bridging neighboring human umbilical cord MSCs obtained from Wharton"s jelly. Characterization studies were carried out through phase contrast, fluorescence, electron microscopy and time lapse images with the aim of describing cells suitable for an eventual regenerative medicine.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comunicação Celular / Nanotubos / Células-Tronco Mesenquimais Limite: Humans Idioma: En Revista: Stem Cell Rev Rep Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comunicação Celular / Nanotubos / Células-Tronco Mesenquimais Limite: Humans Idioma: En Revista: Stem Cell Rev Rep Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos