Your browser doesn't support javascript.
loading
Fecal incontinence and radiation dose on anal sphincter in patients with locally advanced rectal cancer (LARC) treated with preoperative chemoradiotherapy: a retrospective, single-institutional study.
Arias, F; Eito, C; Asín, G; Mora, I; Cambra, K; Mañeru, F; Ibáñez, B; Arbea, L; Viudez, A; Hernández, I; Arrarás, J I; Errasti, M; Barrado, M; Campo, M; Visus, I; Flamarique, S; Ciga, M A.
Afiliação
  • Arias F; Radiation Oncology Department, Complejo Hospitalario de Navarra, Irunlarrea 3, Pamplona, 31008, Spain. fariasde@cfnavarra.es.
  • Eito C; Radiation Oncology Department, Complejo Hospitalario de Navarra, Irunlarrea 3, Pamplona, 31008, Spain.
  • Asín G; Radiation Oncology Department, Complejo Hospitalario de Navarra, Irunlarrea 3, Pamplona, 31008, Spain.
  • Mora I; Radiation Oncology Department, Complejo Hospitalario de Navarra, Irunlarrea 3, Pamplona, 31008, Spain.
  • Cambra K; Department of Statistics, Complejo Hospitalario de Navarra, Pamplona, Spain.
  • Mañeru F; Department of Physics, Complejo Hospitalario de Navarra, Pamplona, Spain.
  • Ibáñez B; Department of Statistics, Complejo Hospitalario de Navarra, Pamplona, Spain.
  • Arbea L; Radiation Oncology Department, Clinica Universitaria de Navarra, Pamplona, Spain.
  • Viudez A; Medical Oncology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.
  • Hernández I; Medical Oncology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.
  • Arrarás JI; Radiation Oncology Department, Clinica Universitaria de Navarra, Pamplona, Spain.
  • Errasti M; Radiation Oncology Department, Clinica Universitaria de Navarra, Pamplona, Spain.
  • Barrado M; Radiation Oncology Department, Complejo Hospitalario de Navarra, Irunlarrea 3, Pamplona, 31008, Spain.
  • Campo M; Radiation Oncology Department, Complejo Hospitalario de Navarra, Irunlarrea 3, Pamplona, 31008, Spain.
  • Visus I; Radiation Oncology Department, Complejo Hospitalario de Navarra, Irunlarrea 3, Pamplona, 31008, Spain.
  • Flamarique S; Radiation Oncology Department, Clinica Universitaria de Navarra, Pamplona, Spain.
  • Ciga MA; Department of Surgery, Complejo Hospitalario de Navarra, Pamplona, Spain.
Clin Transl Oncol ; 19(8): 969-975, 2017 Aug.
Article em En | MEDLINE | ID: mdl-28194687
BACKGROUND: The objective of the study is to determine the correlations among the variables of dose and the sphincter function (SF) in patients with locally advanced rectal cancer treated with preoperative capecitabine/radiotherapy followed by low anterior resection (LAR) + TME. METHODS: We retrospectively reviewed 92 consecutive patients with LARC treated at our center with LAR from 2006 and more than 2 years free from disease. We re-contoured the anal sphincters (AS) of patients with the help of the radiologist. SF was assessed with the Wexner scale (0-20 points, being punctuation inversely proportional to annal sphincter functionality). All questionnaires were filled out between January 2010 and December 2012. Dosimetric parameters that have been studied include V 20, V 30, V 40, V 50, mean dose (D mean), minimum dose (D min), D 90 (dose received by 90% of the sphincter) and D 98. STATISTICAL ANALYSIS: The correlations among the variables of dose and SF were studied by the Spearman correlation coefficient. Differences in SF relating to maximum doses to the sphincter were assessed by the Mann-Whitney test. RESULTS: Mean Wexner score was 5.5 points higher in those patients with V 20 > 0 compared to those for which V 20 = 0 (p = 0.008). In a multivariate regression model, results suggest that the effect of V 20 on poor anal sphincter control is independent of the effect of distance, with an adjusted OR of 3.42. CONCLUSIONS: In order to improve the SF in rectal cancer treated with preoperative radiotherapy/capecitabine followed by conservative surgery, the maximum radiation dose to the AS should be limited, when possible, to <20 Gy.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canal Anal / Neoplasias Retais / Adenocarcinoma / Incontinência Fecal / Quimiorradioterapia Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canal Anal / Neoplasias Retais / Adenocarcinoma / Incontinência Fecal / Quimiorradioterapia Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália